National Repository of Grey Literature 3 records found  Search took 0.00 seconds. 
Association of HSP70 genes with idiopathic inflammatory myopathy in a homogeneous cohort of Czech patients
Svitálková, Táňa ; Novota, Peter (advisor) ; Daňková, Pavlína (referee)
MHC complex is the most polymorphic, most complex and one of the most important parts of a genome which takes a part in the immunity response of an organism. In a human body, it is tagged as HLA (human leukocyte antigen) and consists of 224 genes. HLA genes are associated as a risk factor in numerous autoimmunity diseases. One of systemic autoimunity diseases is idiopathic inflammatory myopathy. It is a disease with a clinical manifestation of a chronical muscle inflammation with a destruction of own cells and leading to a damage of the whole organs. IIM involves several diagnoses - polymyopathy (PM), dermathomyopathy (DM) myopathy associated with tumor diseases (CDM) myopathy with inflammatory inclusion corps (IBM) and others. MHC complex consists of three parts, two of which - MHC class I and II - are already examined rather well and have been associated with numerous (mainly autoimmunity) diseases. Last part of MHC is located between class I and II is an area of around 150 genes called "non Class I/II" (Remáková, Novota, 1999). The main subject for my thesis are three genes of the HLA complex in which has been proven a function in regulation mechanism of some autoimmunity diseases. These genes play a part in the immunity response, because they are able to stimulate the adaptive and native...
Association of HSP70 genes with idiopathic inflammatory myopathy in a homogeneous cohort of Czech patients
Svitálková, Táňa ; Novota, Peter (advisor) ; Daňková, Pavlína (referee)
MHC complex is the most polymorphic, most complex and one of the most important parts of human genome which participates in the immune response. MHC in humans is known as HLA complex (human leukocyte antigen), and consists of about 224 genes (Beck et al., 1999; Robinson et al., 2000). HLA genes are well known risk factors associated with number of autoimmune diseases (Beck et al., 1999). Idiopathic inflammatory myopathy belongs to the systemic autoimmune diseases. It is a disease with clinical manifestation of chronic muscle inflammation with a destruction of muscle cells, leading to a damage of the whole muscles. Idiopathic inflammatory myopathy (IIM) includes several diagnoses - polymyositis (PM), dermatomysitis (DM), cancer associated myositis (CDM), inclusion bodies myositis (IBM), and others. Human MHC complex consists of three parts. First two of them - the MHC class I and MHC class II genes, are already well studied and published results show their associated with numbers of (mostly immune system mediated) diseases. The third part of MHC is located between class I and II antigens and covers an area of about 150 genes. It is also called "non Class I/II" antigens (Beck et al., 1999; Carole et al., 1988; Lie, Thorsby, 2005). My work was focused on three MHC-located genes, which are known to be...

Interested in being notified about new results for this query?
Subscribe to the RSS feed.