National Repository of Grey Literature 19 records found  1 - 10next  jump to record: Search took 0.01 seconds. 
Hlavatá, J. ; Suchý, Tomáš ; Šupová, Monika ; Pokorný, M. ; Košťáková, E.
Collagen makes up one of the most important parts of the extracellular matrix and connective tissue. Collagen type I accounts for up to 90% of the collagen found in the body and it can be isolated and purified in large quantities and processed into a variety of forms. With respect to the process of the treatment of collagen into the nano-fibrous and submicron-fibrous forms, severe conditions leading to the denaturation of the collagen and thus the gelatin content should be avoided. Centrifugal force spinning and electrospinning processes appear to present promising methods for the spinning of collagen solutions. This paper deals with a comparison of the various methods applied in the processing of collagen, i.e. principally needle and needleless centrifugal spinning technology and electrospinning technology. In addition, the effect of process parameters and collagen solution conditions on the final form of the material was analyzed. Spun layers were prepared based on collagen type I isolated from calf skin. Nano-structured layers were prepared employing the spinning of 4-16 wt% collagen solutions in phosphate buffer saline and ethanol. The layers thus prepared were characterized by means of scanning electron microscopy and Fourier transform infrared spectroscopy.
Optimizing and Evaluating the Biocompatibility of Fiber Composites with CaP Additives
Suchý, Tomáš ; Sucharda, Zbyněk ; Balík, Karel ; Sochor, M. ; Bačáková, Lucie
Composite materials based on a polyamide fabric (aramid) and a polydymethyl-siloxane (PDMS) matrix were designed for application in bone surgery. In order to increase the bioactivity, 2, 5, 10, 15, 20 and 25 vol. % of nano/micro hydroxyapatite (HA) and tricalcium phosphate (TCP) were added. The effect of the additives on the biocompatibility was studied. It appears that nano additives have a more favorable effect than micro particles on mechanical properties. For final application of the composites as substitutes for bone tissues, 15 vol. % of nano hydroxyapatite additives is an optimum amount: in this case both the mechanical properties and the biological properties are optimized without distinct changes in the inner structure of the composite.
Contribution of gag region to overall HIV replicative fitness in patients with different disease progression
Suchý, Tomáš ; Weber, Jan (advisor) ; Šmahel, Michal (referee)
Human immunodeficiency virus (HIV) is globally spread virus without available cure. Since its life-long presence, virus is carefully monitored as well as patient's immunological status. Replicative fitness of the virus is one of important aspects which can be taken into account, when monitoring HIV. Here, we are measuring HIV replicative fitness of gag recombinant viruses and comparing the results with replicative fitness of primary isolates. Further, we are comparing our findings of replicative fitness change over time with disease progression in the patient. We found that gag can be major contributor to overall fitness, although not in all cases. Additionally, we observed a correlation of replicative fitness development and slope of patient's CD4+ T cells. Moreover, this relation was even more noticeable in patients with slow disease progression or in carriers of protective alleles. In summary, our results extend the understanding of replicative fitness and its role in disease progression; and pave the way to use the recombinant HIV for replicative fitness measurement in clinical practice. Keywords: HIV, replicative fitness, recombinant virus, HIV disease progression, gag
The role of Interferon regulatory factors in virus infections
Suchý, Tomáš ; Forstová, Jitka (advisor) ; Matyska Lišková, Petra (referee)
Viruses are intracellular parasites, which expose their proteins and nucleic acids during their interaction with a cell. Thanks to co-evolution the host immune system developed mechanims how to recognize these components and subsequently activate defensive mechanisms. This work summarizes the knowledge about selected transcription factors with interferon regulatory function. Induction of the antiviral state is complicated and strictly regulated process. Primary function of selected transcription factors is to connect virus detection and synthesis of cellular molecules with antiviral potential. The work includes information about the direct interaction of viral proteins with interferon regulatory factors. These facts enable us insight into the molecular struggle between a host and a virus. As the name of factors suggests, the most important function is to influence the interferon production. Gathering of information about coordination of the immune system is beneficial for humane medicine and future therapeutic purposes. Key words: interferon regulatory factors; viral infection; regulation of innate immunity; interferon; pathogen recognition
Assessing the Financial Efficiency of a Company Using Time Series Analysis
Suchý, Tomáš ; Melkes, Vladimír (referee) ; Doubravský, Karel (advisor)
This bachelor’s thesis aims to analyze business performance using time series based on selected indicators. The first half of the work focuses on the theoretical basis used for calculations of the time series. In the second half of the work is dealt with practical part. First, here is characterized by the selected firm and are analyzed by selected economic indicators in the evaluation. In the end are calculated for the future forecasts and designed directions, that the company can take.
Analysis of motivation program in AdFinance s.r.o.
Rýznarová, Pavla ; Pauknerová, Daniela (advisor) ; Suchý, Tomáš (referee)
All companies are looking for unordinary competitive advantages in order to be distinguished from the others and to succeed. That is really tough task. Fortunately, people are unique and that's why each person can be considered as a competitive advantage if you are able to handle him and treat him properly. We can influence our employees through their motivation considering their desires, wishes and fears. Motivation is the spark that sets the fire. It gets things started. Highly motivated individuals have willingness to get the job done efficiently and effectively, resulting in higher productivity, increased revenue, cost savings and satisfied employees. The key tool for handling and treating people at work is possession of motivation program which will enable to identify desired behaviors, determine achievable goals, define what constitutes achievement, create a clear plan, communicate the plane and continue to monitor and share results.
The Influence of Steam Sterilization Processes on the Micro- and Macromechanical Properties of Polyamide Fiber-Reinforced PDMS Composites for Medical Device Applications
Sochor, M. ; Balík, Karel ; Sedláček, R. ; Suchý, Tomáš ; Sucharda, Zbyněk ; Šepitka, J. ; Lukeš, J.
The effect of multiple steam sterilization processes on the structural integrity of the polymer matrix composite polydimethylsiloxane (PDMS) reinforced with polyamide fibers (Aramid) is investigated by 3- and 4-point bending tests and by nanoindentation.
Sterilization Decomposition Evaluation of Radiolucent Composite Materials for Use in Medicine
Sochor, M. ; Balík, Karel ; Suchý, Tomáš ; Sedláček, R. ; Sucharda, Zbyněk ; Beneš, J. ; Prokop, J.
This study evaluates the resistance against multiple sterilization processes of radiolucent composite materials for use in medicine as an intraoperative imaging device material. The composite materials under investigation here are composed of carbon fibers, polyphenylene sulfide and polyetheretherketone matrix. The influence of multiple sterilization processes on changes in their mechanical and structural properties are determined. The radiolucency of the proposed composites is verified.
Particulate composites based on nano HA/TCP particles for bone graft replacements
Suchý, Tomáš ; Rýglová, Šárka ; Balík, Karel ; Sucharda, Zbyněk ; Denk, F.
Particulate composite materials have been developed for applications in the form of an intervertebral cage (for use in spine treatment). The intervertebral cage is composed of a bearing cage made of PEEK and a composite core with the surface contacting the bone surface and ensuring elastic linkage of two vertebral bodies, resulting in good adhesion to the bone. Mechanical analysis of different kinds of particulate composites was performed. The effect of hydroxyapatite and tri-calcium phosphate nanofiller volume fractions on the mechanical properties of particulate composites was investigated.
Biocompatibility optimization of fabric composites by calcium phosphates
Sochor, M. ; Balík, Karel ; Suchý, Tomáš ; Sucharda, Zbyněk
Composite materials based on a polyamide fabric and a polydimethylsiloxane matrix were designed for application in bone surgery. In order to increase the bioactivity, 2, 5, 10, 15, 20 and 25 vol. % of nano/micro hydroxyapatite and tricalcium phosphate were added. The effect of the additives on the mechanical properties was studied. Simultaneously, changes in the inner structure of the composites were investigated by means of image analysis.

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2 Suchý, T.
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