National Repository of Grey Literature 60 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Spatial Navigation Impairment as An EarlyMarker of Neurodegenerative Disease
Mokrišová, Ivana ; Hort, Jakub (advisor) ; Stuchlík, Aleš (referee) ; Vymazal, Josef (referee)
Aging of population with related increase of incidence of neurodegenerative diseases mostly Alzheimer disease (AD), poses a serious socioeconomic problem. In the recent years, research has been focused on specific early disease markers and identifications of patient's populations at increased risk of AD, which comprise mild cognitive impairment (MCI) and subjective cognitive decline (SCD) which may represent prodromal and preclinical stage of AD, while still preserving functional capacity. This thesis summarizes and further extends current knowledge in the field of AD with a specific focus on early disease markers. The main topic of the thesis is spatial navigation, especially its allocentric component and path integration. Examination of spatial navigation might serve as the valuable diagnostic tool which could be used in wider clinical practice for timely diagnostics, disease monitoring and also for evaluation of the treatment effect. We also present here experimental tests (questionnaires of subjective spatial navigation complaints and tests of visual perception) that have enough sensitivity and specificity for identification of subjects at risk for AD.
Coding of stable and moving objects in the brain
Lobellová, Veronika ; Stuchlík, Aleš (advisor) ; Telenský, Petr (referee)
Spatial navigation in an environment is essential for one's survival. Animals need to monitor location of self and location of other animate or inanimate objects. Navigation is a hippocampus dependent process supported by activity of place cells. Object location in space is thought to be coded as a point of interest on cognitive map formed by place cells. Place cells change their firing fields, process known as remapping, when a new object is introduced into the environment. However we do not yet know how location of moving objects such as predators or other animals is presented on the cognitive map. This work summarizes findings of chosen studies concerning the role of hippocampus and place cells in spatial coding of stable and moving objects.
Role of glutamate in obsessive-compulsive disorder: clinical and experimental findings
Mainerová, Karolína ; Stuchlík, Aleš (advisor) ; Fajnerová, Iveta (referee)
Obsessive - compulsive disorder is a common and chronic illness that decreases quality of life and leads to serious limitations. Its treatment is currently only successful in some patients and many of them remain with their problems without proper help and medication. The exact cause of the disease is not yet known, but the role of the glutamatergic system in the pathophysiology of obsessive-compulsive disorder is apparently very important and its modulation can potentially lead to increase in treatment success. Animal models of genetic, behavioural, pharmacological and optogenetic origins are very useful in gaining new insights into the principles and underlying causes of the disease. Clinical studies indicate the efficacy of glutamatergic modulators for disease manifestations and could serve as new avenues for the development of new drugs. Key words: obsessive-compulsive disorder (OCD); glutamate, animal model, clinical findings
Role of interneurons and neural circuit dysfunctions in Alzheimer's disease
Rakovets, Yuliia ; Stuchlík, Aleš (advisor) ; Červená, Kateřina (referee)
Alzheimer's disease is one of the most common neurodegenerative disorder that results in altered network activity, in particular cognitive decline. Majority people with AD experience memory impairment, poor judgment, disorientation and learning difficulties. Several hypotheses try to explain the cause of the disease, but it's poorly understood. Due to the fact that changes in brain structure arise years before clinical symptoms emerge, the available therapeutic treatments can only reduce the impact of neurodegeneration, but not to reverse. Interneurons, as a part of neural circuits, play an important role in the formation of cognitive abilities. Most of interneurons in CNS are inhibitory and they effectively control the network synchrony. Network hypersynchrony is an increased synchronization of neural activity and it's linked to AD pathology. Dysfunction of interneurons is resulted in altered network activity in patients with AD. Keywords: AD, brain, rat, interneurons, hypersynchrony.
Dysfunctions of interneurons in schizophrenia
Hrůzová, Karolína ; Stuchlík, Aleš (advisor) ; Weissová, Kamila (referee)
Schizophrenia is a serious neuropsychiatric disorder characterised by abnormal behaviours, perception and thoughts. It is a neurodevelopmental disease of two types of factors - genetic predispositions and environmental factors. The exact cause of schizophrenia remains, however, elusive. Interneurons are types of neurons, mostly exerting inhibitory action and their dysfunctions are associated with pathogenesis of schizophrenia. They are essential in the generation of neuronal oscillations, which play an important role in cognitive functions. Disruption of these oscillations (especially gamma band) could be paralleled by negative, positive or cognitive symptoms of schizophrenia. These interactions could be possible discerned with an innovative technique called optogenetics. Optogenetics is a combination of genetic and optical approaches to controlling activity of specific targeted neurons. With this method we can study animal models of schizophrenia with great insight, which could give us an explanation of abnormalities in behaviour caused by neuronal disruption. Keywords: schizophrenia; interneurons; animal models; neuronal oscillations; optogenetics
Block Cejl – Svitava RIver Waterfront
Kučera, Vít ; Stuchlík, Aleš (referee) ; Havliš, Karel (advisor)
This thesis explores possibilities of postindustrial area in Brno, between Cejl street and Svitava river. It presents a hint on author's understanding of architecture and urbanism as well as his oppinion on solved problems. Thesis consists of three parts. First part analyzes possibilities, values and limits of the area. Second part presents proposed urban concept for solved area. Last part further solves concept for three building from beforementioned urban concept.
Block Cejl – Svitava RIver Waterfront
Kůřil, Filip ; Stuchlík, Aleš (referee) ; Havliš, Karel (advisor)
Bachelor thesis deals with the analysis and design of the reconstruction of the block between Cejl street and Svitavy embankment. The proposal seeks to create urban housing on the site of the current brownfield.

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