National Repository of Grey Literature 18 records found  1 - 10next  jump to record: Search took 0.00 seconds. 
Role of microbiota in mouse experimental model of psoriasis
Jirásková Zákostelská, Zuzana ; Stehlíková, Zuzana ; Klimešová, Klára ; Rossmann, Pavel ; Dvořák, Jiří ; Novosádová, Iva ; Kostovčík, Martin ; Coufal, Štěpán ; Šrůtková, Dagmar ; Hudcovic, Tomáš ; Štěpánková, Renata ; Rob, F. ; Jůzlová, P. ; Herzogová, J. ; Tlaskalová-Hogenová, Helena ; Kverka, Miloslav
Anotace v anglickém jazyce\n\nMouse model of human psoriasis and gnotobiotic are important tools in understanding the role of gut and skin microbiota in pathogenesis of psoriasis. In our experiments we showed that gnotobiotic mice, as well as conventional mice treated with antibiotics, have milder skin inflammation in comparison with control conventional mice. Treatment with broad spectrum antibiotics led to dramatic shift in gut microbial composition, in particular, we observed extensive increase of order Lactobacillales. To analyze the potential effect of Lactobacillales on skin inflammation, we further monocolonized mice with L. plantarum WCFS1. Also monocolonized mice showed lower skin inflammation in comparison with conventional mice. To understand whether microbial dysbiosis is cause or effect of psoriasis needs to be further investigated.\n\n
Gut microbiome and colorectal cancer
Tlaskalová-Hogenová, Helena ; Klimešová, Klára ; Zákostelská, Zuzana ; Kverka, Miloslav ; Hornová, Michaela ; Vannucci, Luca ; Štěpánková, Renata ; Hudcovic, Tomáš ; Kozáková, Hana ; Rossmann, Pavel
The work deals with metagenomic approaches that are currently being used to decipher the genome of the microbiota (microbiome), and, in parallel, functional studies are being performed to analyze the effects of microbiota on the host.
Immunomodulatory effects of bacterial lysate of Lactobacillus casei DN-1140001 on the formation and evolution of experimentally induced intestinal inflammation
Zákostelská, Zuzana ; Kverka, Miloslav ; Rossmann, Pavel ; Klimešová, Klára ; Mrázek, Jakub ; Kopečný, Jan ; Tlaskalová-Hogenová, Helena
Lactobacillus casei DN 114 001 belongs to one of the most studied probiotics today. The aim of this study was to determine whether this fraction isolated from probiotics can alleviate the course of intestinal inflammation
Polymerní konjugát doxorubicinu na bázi HPMA, působící ve shodě s protinádorovou imunitou nositele
Šírová, Milada ; Rossmann, Pavel ; Mrkvan, Tomáš ; Strohalm, Jiří ; Šubr, Vladimír ; Plocová, Daniela ; Ulbrich, Karel ; Říhová, Blanka
Polymeric conjugate Dox-HPMA-HuIg directly targets the tumour due to the EPR effect, it is not detrimental towards the immune system of the host, and acts in concert with the anti-tumour immune responses
Morfologické změny při karcinomu tlustého střeva vyvolaném u myší azoxymethanem a natrium dextransulfátem
Klimešová, Klára ; Rossmann, Pavel ; Kverka, Miloslav ; Frolová, Lenka ; Tlaskalová, Helena
This study confirmed an important role of inflammation in colon carcinogenesis. Developing of tumors is usually closely associated with the areas of inflammation
Perorální podání živých probiotických bakterií ovlivňuje závažnost experimentální akutní kolitidy u Balb/c myší
Kokešová, Alena ; Sokol, Dan ; Bártová, J. ; Rossmann, Pavel ; Tlaskalová, Helena
Our data extend the evidence that non-pathogenic luminal bacteria participate in the pathogenesis of chronic intestinal inflammation. Administration of probiotic bacteria influencing the composition of intestinal flora may be relevant to the development of novel strategies in the prevention and management of IBD patiens
Exprese toll-like receptorů 2 a 4 a CD14 ve střevní mukóze u pacientů s nespecifickými střevními záněty (NSZ)
Frolová, Lenka ; Drastich, P. ; Klimešová, Klára ; Rossmann, Pavel ; Tlaskalová, Helena
This study show that IBD may be associated with increased expression of TLR2 and CD14 in the intestinal epithelium of the patients

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