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Národní úložiště šedé literatury Nalezeno 3 záznamů.  Hledání trvalo 0.01 vteřin. 
Conformation analysis of nucleoside analogues containing selenium and tellurium in five-membered pseudosugar ring
 Poštová Slavětínská, Lenka ; Pohl, Radek ; Rejman, Dominik
The conformation analysis of synthetized thymine and adenosine nucleoside analogues with selenium and tellurium in five-membered pseudosugar ring has been studied. The experimental NMR measurement was complemented with DFT molecular modeling studies. It was found, that ratio between individual conformers in solution depends on the nature of the heteroatom in the five-membered pseudosugar ring.
Úplný záznam
Pyrrolidine nucleotides conformationally constrained via hydrogen bonding
 Pohl, Radek ; Poštová Slavětínská, Lenka ; Rejman, Dominik
Conformation of pyrroPME nucleotide analogues was studied by means of NMR at different pD values in D2O solutions. Surprisingly, two stable conformers were found at pD > 9 for both cis and trans configurations and their ratio depended on the acid-base properties of nucleobase attached to pyrrolidine ring. The results of conformational analysis suggest that the conformation of the pyrrolidine ring is locked via intramolecular hydrogen bond between negatively charged phosphonate oxygen atom and protonized pyrrolidine nitrogen.
Úplný záznam
Oligonucleotides modified with acyclic nucleoside phosphonate (HPEP) units
 Kaiser, Martin Maxmilian ; Novák, Pavel ; Rosenbergová, Šárka ; Poštová Slavětínská, Lenka ; Rosenberg, Ivan ; Janeba, Zlatko
Two acyclic nucleoside phosphonates bearing 9-[3-hydroxy-2-(phosphonoethoxy)propyl] (HPEP) moiety and either adenine and thymine as nucleobase were synthetically converted into a suitable building blocks for the subsequent automated solid phase synthesis of modified oligonucleotides. Phosphoramidite chemistry was used for the synthesis of a series of complementary nonamers where the modified acyclic monomers were incorporated using the phosphotriester method. Determination of thermal characteristics of the complexes of the modified nonamers with the complementary strands revealed a destabilizing effect of the introduced acyclic modifications.
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