National Repository of Grey Literature 21 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Baseline Hematologic Parameters Influencing Outcomes in Patients with Locally Advanced Rectal Cancer
Hodek, Miroslav ; Petera, Jiří (advisor) ; Feltl, David (referee) ; Soumarová, Renata (referee)
Baseline Hematologic Parameters Influencing Outcomes in Patients with Locally Advanced Rectal Cancer Aim of the study: The link between the blood count and a systemic inflammatory response (SIR) is indisputable and well described. Pretreatment hematological parameters may predict the overall clinical outcomes in many types of cancer. Thus, this study aims to systematically evaluate the relationship between baseline blood count levels and treatment response in rectal cancer patients treated with neoadjuvant chemoradiotherapy. Patients and methods: From 2009-2015, 173 patients with locally advanced rectal cancer were retrospectively enrolled in the study and analyzed. The baseline blood count was recorded in all patients 1 week before chemoradiation. Tumor response was evaluated through pathologic findings. Blood count levels which included RBC (red blood cells), Hb (hemoglobin), PLT (platelet count), neutrophil count, WBC (white blood cells), NLR (neutrophil-to-lymphocyte ratio), and PLR (platelet-to-lymphocyte ratio) were analyzed in relation to tumor downstaging, pCR (pathologic complete response), OS (overall survival), and DFS (disease-free survival). Results: Hb levels were associated with a response in logistic regression analysis: pCR (p = 0.05; OR 1.04, 95% CI 1.00-1.07); T downstaging (p =...
The impact of PET/CT scanning in the radioteraphy planning of non-small cell lung cancer
Vojtíšek, Radovan ; Petera, Jiří (advisor) ; Feltl, David (referee) ; Zemanová, Milada (referee)
The impact of PET/CT scanning in the radiotherapy planning of non-small cell lung cancer Background: In the current practice of radiotherapy planning and target volume determination in patients suffering from the non-small cell lung cancer (NSCLC), a contrast-enhanced CT is standard procedure. Contemporary studies have proven that PET/CT examination attains higher sensitivity and specificity in the diagnosis of lung cancer and also leads to higher accuracy in the process of target-volume delineation in NSCLC. Aim: To compare radiotherapy plans made according to CT and PET/CT examinations in the same patient and to investigate the impact of changes in target volume sizes on tumor control probability (TCP) and normal tissue complication probability (NTCP) and the impact of combined PET/CT examination on the staging of the disease and treatment strategy. Materials and Methods: Between October 2008 and November 2013, 42 patients suffering from pathologically proven inoperable locally advanced NSCLC that were referred to radical radiotherapy were involved in our study. They all underwent planning PET/CT examination. I carried out two separate delineations of target volumes and two radiotherapy plans, both with their own dose-volume histograms (DVH). I compared the following parameters of radiotherapy...
The role of human papilloma viruses in ethiopathogenesis malignant tumors in sinonasal area
Sieglová, Kateřina ; Nachtigal, Petr (advisor) ; Petera, Jiří (referee)
The aim of this thesis is the comparison of immunohistochemical and molecular biological methods for the detection of human papillomavirus (HPV) in tumour tissue and their subsequent use in the study of HPV role in the etiopathogenesis of malignant tumors of sinonasal region. Several methods for the purpose of HPV detection were applied: in situ hybridization, immunohistochemical detection of expression of p16INK4a protein, classic polymerase chain reaction combined with two different enzyme immunoassay detection methods, and reverse hybridization, followed by polymerase chain reaction with real time reverse transcription. All methods (p16 DNA in situ hybridization, RNA in situ hybridization, quantitative polymerase chain reaction with reverse transcription - RT-qPCR mRNA) used for the detection of HPV performed very well when compared, showing concordance with statistical significance p ˂ 0,0001. Detection of p16 vs. DNA polymerase chain reaction (PCR) had correlation coefficient p = 0.004 in the whole group, and p = 0.002 in the subgroup of squamous cell carcinoma (SCC). Correlation coefficient between detection of p16 and overall HPV status was 0,659 for entire set and 0,864 for set of SCC, indicating significant linear dependence. Immunohistochemical detection of p16 in combination with the...
ATM and TGFB1 polymorphism in prediction of late complications of chemoreadiotherapy in patients with locally advanced cervical cancer
Paulíková, Simona ; Petera, Jiří (advisor) ; Kubecová, Martina (referee) ; Fínek, Jindřich (referee)
Cervical cancer is due to high incidence the third most commonly diagnosed gynecological cancer in the Czech republic. More than 50% of these tumors are diagnosed in advanced stage (st. IIB and higher) and therapy is more difficult than in lower stage tumors. The standard treatement method for locally advanced cervical cancers is combined oncological therapy including external beam radiotherapy, brachytherapy and concomitant chemotherapy. This treatement provides good tumor control, but there is also a risk of late complications in irradiated area. Severe late complications affect 10-15% of patients. It is still not possible to predict late complications and therefore detection of valid predictive factors for high tissue radiosensitivity could help to identify patients with increased risk before therapy. Knowledge of such predictive factors would also help to individualize the treatement. New molecular biological methods brought new findings about cancerogenesis, cell cycle regulation and cellular reaction to the radiation damage. It was hypothized, that mutation of genes involved in DNA damage reparation or cell proliferation are one of causes of high tissue radiosensitivity. The aim of our study was to evaluate relations between ATM and TGFß1 polymorphisms and late tissue toxicity in patients treated for...
The role of human papilloma viruses in ethiopathogenesis malignant tumors in sinonasal area
Sieglová, Kateřina ; Nachtigal, Petr (advisor) ; Petera, Jiří (referee)
The aim of this thesis is the comparison of immunohistochemical and molecular biological methods for the detection of human papillomavirus (HPV) in tumour tissue and their subsequent use in the study of HPV role in the etiopathogenesis of malignant tumors of sinonasal region. Several methods for the purpose of HPV detection were applied: in situ hybridization, immunohistochemical detection of expression of p16INK4a protein, classic polymerase chain reaction combined with two different enzyme immunoassay detection methods, and reverse hybridization, followed by polymerase chain reaction with real time reverse transcription. All methods (p16 DNA in situ hybridization, RNA in situ hybridization, quantitative polymerase chain reaction with reverse transcription - RT-qPCR mRNA) used for the detection of HPV performed very well when compared, showing concordance with statistical significance p ˂ 0,0001. Detection of p16 vs. DNA polymerase chain reaction (PCR) had correlation coefficient p = 0.004 in the whole group, and p = 0.002 in the subgroup of squamous cell carcinoma (SCC). Correlation coefficient between detection of p16 and overall HPV status was 0,659 for entire set and 0,864 for set of SCC, indicating significant linear dependence. Immunohistochemical detection of p16 in combination with the...
Combined treatment of advanced head and neck cancer with radiotherapy and cycooxygenase-2 inhibitors (phase I study)
Halámka, Magdalena ; Petera, Jiří (advisor) ; Soumarová, Renata (referee) ; Kubeš, Jiří (referee)
Combined treatment of advanced head and neck cancer with radiotherapy and cycooxygenase-2 inhibitors (phase I study) This paper describes the course and presents the outcomes of a original phase I study of combined treatment of advanced head and neck cancer using standard radiotherapeutic technique and COX2 inhibitor (Celebrex) as a potentiating agent. The primary goal of the study was identifying of the maximum tolerated dose of Celebrex for the purpose of further clinical investigation. In the theoretical introduction I present data on the incidence and mortality of HaN cancer worldwide and in the Czech republic, further preclinical data justifying use of Celebrex in combined treatment with radiotherapy. Special emphasis was put on presentation of local data systematically gained in Clinic of Oncology in Ostrava where this study has been conducted. These data include an overview of incidence, mortality, therapeutic methods and treatment toxicity profiles. Since the phase I study as such does not include comparison with control patient group, it is necessary to be aware of local standards. This is the background to establish inclusion criteria for patient recruitment, toxicity evaluation and setting maximum tolerance dose criteria. This study furthermore investigates expression of COX2 in tumor tissue and...
Pyrimidine metabolism in the environment of post-radiation chemotherapy response - a model for determining the optimal scheme chemoradiotherapy
Vítek, Pavel ; Rosina, Jozef (advisor) ; Zámečník, Jiří (referee) ; Petera, Jiří (referee)
Objectives of thesis research: 1.2 Primary objectives - Identify part-time post-radiation reactions, respectively. determine the dynamics of induction of expression of certain genes involved in its product in the metabolism of fluorinated pyrimidine. - Identify relevant increases in respective protein. - Some developments TP / DPD ratio. 2.2 Secondary objectives - Verify the model fluorinated pyrimidine potentiation of radiation as a basis for supraaditivní chemoradiaci in effect. - Determine the optimal scheme for the application of fluorinated pyrimidine in fractionated radiation application.
Epidermal growth factor receptor as a predictor of tumor response to preoperative chemoradiation in locally advanced gastric carcinoma
Sirák, Igor ; Petera, Jiří (advisor) ; Šlampa, Pavel (referee) ; Soumarová, Renata (referee)
The purpose of my doctoral thesis was a retrospective evaluation whether the intensity of epidermal growth factor receptor (EGFR) expression in tumor biopsy predicts tumor response to preoperative chemoradiotherapy in patients with locally advanced gastric carcinoma. Thirty-six patients with gastric adenocarcinoma in clinical T2-4 stage and/or with nodal metastases were studied. Preoperative treatment consisted of 30-45 Gy of gastric irradiation with continuous 5-fluorouracil and weekly cisplatin. Surgical resection was performed 4-6 weeks later. EGFR expression in pretreatment tumor biopsies was assessed by immunohistochemistry. Level of EGFR expression was determined from the intensity and extent of staining. Tumor response after chemoradiotherapy was defined as a reduction of at least one T-stage level and/or finding of intense tumor regression in histopathologic examination. Seventeen patients responded to preoperative chemoradiation - 8 patients (22%) had pathologic complete response, 9 patients (25%) were downstaged. Positive EGFR expression was found in 8 tumors (22%), and represented a significant predictive marker of poor tumor response in multivariate logistic regression analysis (p = 0.015). Response to chemoradiotherapy was found in 57% (16/28) of EGFR negative patients and in 13% (1/8)...
Forecast models construction of gold and silver prices
Tůmová, Petra ; Petera, Jiří (advisor)
Diplomová práce je zaměřena na analýzu vývoje časových řad, nominálních cen zlata a stříbra od roku 1968 do roku 2014 a následné využití ARIMA modelu pro sestavení predikce cen obou komodit. Při sestavování predikce bylo využito statistického softwaru Statistica od společnosti StatSoft ČR s. r. o. (licence získána z ČZU) a tabulkového procesoru Microsoft Excel.

National Repository of Grey Literature : 21 records found   1 - 10nextend  jump to record:
See also: similar author names
1 Petera, Jan
2 Petera, Jaromír
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