National Repository of Grey Literature 4 records found  Search took 0.00 seconds. 
DISP3/PTCHD2 function in neural cells
Konířová, Jana ; Bartůněk, Petr (advisor) ; Anděrová, Miroslava (referee) ; Pacherník, Jiří (referee)
DISP3 protein, also known as PTCHD2, belongs to the PTCHD family of proteins, which contain a sterol-sensing domain in their structure. The expression of the Disp3 gene is high in neural tissues and is regulated by thyroid hormone. The DISP3 gene is associated with development and progression of certain types of tumors, as well as with development of some neural pathologies. Neural stem cells also display high expression of the Disp3 gene. Neural stem cells are defined by their capability to self-renewal and capacity to differentiate into the basic types of neural cells - neurons, astrocytes, and oligodendrocytes. Precise regulation of the balance between proliferation and differentiation of neural stem cells is crucial for development of the central nervous system and its subsequent proper functioning, and disruption of this balance may lead to development of various pathologies. In this work we mainly focused on describing the function of the DISP3 protein in neural cells and tissues. We have shown that during differentiation of neural stem cells, the expression of the Disp3 gene is significant decreased. Furthermore, we have found that in neural stem and progenitor cells, the increased expression of the Disp3 gene promotes their proliferation. Moreover, when Disp3 expression was disrupted, the...
Interactions of Antimicrobial Agents with Drug renal Transport Systems in Vitro
Mandíková, Jana ; Trejtnar, František (advisor) ; Pacherník, Jiří (referee) ; Mičuda, Stanislav (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate Mgr. Jana Mandíková Supervisor doc. PharmDr. František Trejtnar, CSc. Title of Doctoral Thesis Interactions of antimicrobial agents with drug renal transport systems in vitro A number of important and frequently used antimicrobial agents are excreted from the body through the kidneys. During this excretory process drugs may interact with different membrane transport systems (transporters) which are expressed in the renal tissue. These interactions are often the determining factors for both renal excretion, and the toxic effects of these drugs in the kidney. There are highly expressed influx transporter such as organic anion transporters (OATs), organic cation transporters (OCTs) and the concentrative nucleoside transporters (CNTs) and efflux transporter BCRP (breast cancer resistance protein) and P glycoprotein (P-gp) in the kidney. Despite the importance of renal drug transporters for elimination and nephrotoxic effects of drugs and intensive research in this field, interactions of a number of important antimicrobial drugs with transporters in the kidney are not known or sufficiently described. The aim of this study was to investigate the interaction of selected antivirals and...

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1 Pacherník, J.
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