National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Quality of Life in Patients with Head and Neck Tumors
Doležalová, Helena ; Šimůnek, Antonín (advisor) ; Kubecová, Martina (referee) ; Pála, Miloslav (referee)
2. Summary Quality of life in patients with head and neck tumors The prevalence of head and neck tumours constantly increasing in the last decades represents the serious medical and social problem. The retrospective assessment of the quality deals with the quality of life in patients with early stages of oral cavity tumours after the high dose rate brachytherapy treatment (HDR BRT). The quality of life has been evaluated in 14 patients treated at the Department of Oncology and Radiotherapy, University Hospital Hradec Kralove for early onset of oral cavity tumour using the high dose rate brachytherapy treatment. The standardized EORTC QLQ- C30 and EORTC QLQ-H&N35 questionnaires have been used in this study. The evaluation of the questionnaires was performed 12 months after the treatment. General health status using the EORTC QLQ-C30 was scored with 70 points. The most severe reported symptoms were fatigue, insomnia, loss of appetite, dyspnoea and financial problems. The main problems being identified by EORTC QLQ-H&N35 were weight gain, cough, pain, sticky saliva and social eating. On the contrary weight loss, speech impairments, difficulties in mouth opening, swallowing and sensory problems were not considered as significant ones. The quality of life in individuals treated with the high dose rate...
Radiochemotherapy with weekly cisplatin in the treatment of head and neck cancer
Pála, Miloslav ; Odrážka, Karel (advisor) ; Soumarová, Renata (referee) ; Klozar, Jan (referee)
Radiochemotherapy with weekly cisplatin in the treatment of head and neck cancer. Purpose: The objective of this study was to evaluate the feasibility, toxicity and efficacy of postoperative and definitive radiochemotherapy with weekly cisplatin in locoregionally advanced or high risk head and neck cancer. Material and methods: Patients with head and neck cancer of stage III-IVb or patients with insufficient margins of resection after initial surgery were included in the study of postoperative radiotherapy. Radiotherapy consisted of 70 Gy/ 7 weeks/ 35 fraction after R1/2 resection and 60- 64 Gy/ 6-6,5 weeks/ 30-32 fraction after R0 resection, respectively. Patients with head and neck cancer of stage II-IVb without initial resection were included in the study of definitive radiochemotherapy. Radiotherapy consisted of 70 Gy / 7 weeks / 35 fraction. All patients received concurrent cisplatin 40 mg/m2 weekly. Results: Postoperative radiochemotherapy: Between 6/2002 and 12/2008, 100 consecutive patients WHO  2, male to female ratio 84/16, median age 54 years were treated. Tumours of the oropharynx were the most frequent (49%) and stage IV was predominant (86%). 96% patients received the full radiation treatment as planned. Median total tumor dose was 66 Gy. Omission of weekly cisplatin had been...

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