National Repository of Grey Literature 108 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Polycyclic aromatic hydrocarbons in PM1 aerosol in 6 localities in the Czech Republic
Křůmal, Kamil ; Mikuška, Pavel
PAHs were measured in winter seasons in cities/towns Ostrava-Radvanice (industrial city), Brno, Mladá Boleslav, Kladno-Švermov, Čelákovice, Košetice (background town). Lifetime lung cancer risks of PAHs were calculated from concentrations of PAHs in PM1 aerosol.
Determination of fast changes in concentrations of volatile organic compounds using diffusion denuder
Křůmal, Kamil ; Mikuška, Pavel
Determination of fast changes in concentrations of volatile organic compounds was performed using wet effluent diffusion denuder, which allows collection of samples in 2-min intervals.
GENE EXPRESSION AND IMMUNOLOGICAL RESPONSE IN MICE EXPOSED TO ZnO NANOPARTICLES
Rössner ml., Pavel ; Vrbová, Kristýna ; Strapáčová, S. ; Rössnerová, Andrea ; Ambrož, Antonín ; Brzicová, Táňa ; Líbalová, Helena ; Javorková, Eliška ; Zajícová, Alena ; Holáň, Vladimír ; Kulich, P. ; Večeřa, Zbyněk ; Mikuška, Pavel ; Coufalík, Pavel ; Křůmal, Kamil ; Čapka, Lukáš ; Dočekal, Bohumil ; Šerý, Omar ; Machala, M. ; Topinka, Jan
We analyzed gene expression changes in the lungs and the immunological response in splenocytes of mice exposed by inhalation of ZnO nanoparticles - NP. Adult female ICR mice were treated for three days and three months, respectively. Analysis of differential expression in genes involved in oxidative stress was conducted using quantitative RT-PCR. The potential immunotoxic and immunomodulatory effects of ZnO NP were analyzed by phenotyping and cytokine production by splenocytes after three months exposure. Three days exposure resulted in down-regulation of GCLC, GSR, HMOX-1, NQO-1, NF-kB2, PTGS2 and TXNRD1 mRNA expression, three months exposure increased the expression of these genes. Three months exposure caused a significant decrease in the percentage of granulocytes in the spleen cells, and affected the production of IL-10 and IL-6 by lipopolysaccharide-stimulated leukocytes. In summary, our study revealed changes in the expression of genes involved in the oxidative stress response following acute ZnO NP exposure. Subchronic ZnO NP exposure induced immunomodulatory effects in the spleen.
Oxidative potetial of atmospheric aerosol as indicator of ROS formation
Barboříková, Hana ; Mikuška, Pavel ; Hegrová, J. ; Krajčovič, J.
Atmospheric particulate matter (PM) affects our environment especially human health because it contains many toxic chemical substances. The purpose of this study is to determine a total content and a soluble fraction of selected metals and also the contribution of metals soluble in pulmonary fluids to a total oxidative potential of PM.
Chemical composition of aerosol particles in emissions from coal combustion in different boilers used for residential heating
Křůmal, Kamil ; Mikuška, Pavel ; Horák, J. ; Hopan, F.
Organic compounds (polycyclic aromatic hydrocarbons, alkanes) and organic markers (hopanes) used for the identification of aerosol emission sources were measured in emissions from the combustion of hard and brown coal. Coal was combusted in different boilers (overfire boiler, boiler with down-draft combustion and automatic boiler) used for residential heating in the Czech Republic.
Effect of inhaled metal oxide nanoparticles on organs of exposed mice
Mikuška, Pavel ; Večeřa, Zbyněk ; Dočekal, Bohumil ; Čapka, Lukáš ; Křůmal, Kamil ; Coufalík, Pavel ; Moravec, Pavel ; Buchtová, Marcela ; Míšek, Ivan ; Vrlíková, Lucie ; Smutná, Tereza ; Dumková, J. ; Hampl, A. ; Fictum, P.
Adult mice were continuously exposed to metal oxide nanoparticles for different time intervals. At the end of experiment, mice organs (lung, brain, kidney, liver and spleen) were collected for chemical, biochemical, histological and electron microscopical analyses.
Determination of dicarboxylic acids in air by aerosol sampler
Čapka, Lukáš ; Mikuška, Pavel
Dicarboxylic acids (DCAs) are important components of water soluble aerosol compounds. Aerosol particles are quantitatively collected using a continous aerosol sampler, CGU-ACTJU, into deionized water. The ACTJU effluent is permanently sucked out from the sampler and on-line analysed for DCAs content by means of ion chromatography.
Regional Air Pollution Transport and Its Influence to Pollution Hotspot in th Czech Republic.
Kozáková, Jana ; Vodička, Petr ; Pokorná, Petra ; Ondráčková, Lucie ; Ondráček, Jakub ; Hovorka, J. ; Křůmal, Kamil ; Mikuška, Pavel ; Moravec, Pavel ; Schwarz, Jaroslav
The aim of the study was to find out the local effect and the regional air pollution transport effect on the air quality of the Ostrava Radvanice district, the problematic air pollution hot spot.
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Characterization of organic compounds in PM1aerosol in Kosetice and Brno in winter season 2017
Křůmal, Kamil ; Mikuška, Pavel ; Večeřa, Zbyněk
In this work, the organic compounds and organic markers used for the identification of sources of aerosols were measured. Monosaccharide anhydrides and resin acids (emissions from biomass combustion) and polycyclic aromatic hydrocarbons (emissions from traffic and incomplete combustion) were observed especially. Hopanes, steranes (traffic, coal combustion) and alkanes were next groups of analysed organic compounds.
Determination of levoglucosan and dehydroabietic acid in urban aerosol
Coufalík, Pavel ; Čmelík, Richard ; Křůmal, Kamil ; Čapka, Lukáš ; Mikuška, Pavel
The analytical method involving aerosol sampling into water, quantitative pre-concentration of levoglucosan and dehydroabietic acid, and their determination by LC-MS was developed in this work.

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