National Repository of Grey Literature 108 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Monetary Policy Transmission - Bank Lending Channel and Banking Market Structure. The Case of Georgia, Azerbaijan, and Armenia.
Jvaridze, Tinatin ; Mareš, Jan (advisor) ; Komárek, Luboš (referee)
In the thesis, we examine the bank lending channel and the effect of banking market structure on the transmission of monetary policy in Georgia, Armenia, and Azerbaijan. We employ bank-level data for the period of 2011-2017 to detect if banks with different characteristics react differently to monetary policy shocks. Banking market structure is proxied by three measures-CR5, HHI, and Lerner Index. We estimate two types of models: dynamic (with system GMM) and static (with FE) models. We also consider the effect of dollarization on bank loan supply as well as on monetary policy. We do not find consistent evidence that banks react differently to monetary policy shocks depending on bank characteristics (size, capitalization, and liquidity). Hence the existence of the lending channel is not conclusive. Nevertheless, the results show that monetary policy is less effective in more concentrated markets. This finding is robust in all specifications with both types of models. In this sense, competition is not significant. The results also suggest that dollarization weakens the effect of domestic monetary policy. Keywords bank lending channel, CR5, HHI, Lerner Index, system GMM, dollarization Author's e-mail t.jvarize@yahoo.com Supervisor's e-mail janxmares@gmail.com
Experimental Study of Mechanisms of Neurodegeneration in Different Conditions
Purkartová, Zdeňka ; Vožeh, František (advisor) ; Pokorný, Jaroslav (referee) ; Mareš, Jan (referee)
EXPERIMENTAL STUDY OF MECHANISMS OF NEURODEGENERATION IN DIFFERENT CONDITIONS - SUMMARY MUDr. Zdeňka Purkartová The cerebellum is an important structure involved in motor coordination and many other functions including cognitive and emotional processes. Severe cerebellar diseases include a wide group of cerebellar hereditary degenerations with different types of heredity, different pathogenesis and diverse phenotypic manifestation. Many types of mouse models can be used to investigate these diseases and their therapy. These mice carry spontaneous mutations or are genetically modified. The aim of this work was to analyse the dynamics of morphological changes of cerebellar degeneration in Lurcher mice using fluorescent double staining. We also performed transplantation of embryonic cerebellar tissue suspension in adult Lurcher B6CBA mice, B6.BR mice and wild-type mice of both strains with two-month survival after surgery and transplantation of identical suspension in adult Lurcher B6CBA mice and C3H mice and wild- type mice of both these strains with six-month survival after surgery. We have confirmed these main characteristics of the degenerating Purkinje cells in Lurcher mutants: the disrupted continuity of the Purkinje cell layer, the presence of dark spots in the cell nuclei, the fragmentation of nuclei...
Proteomics, Lymphocyte Population in Multiple Sclerosis and Disability
Pavelek, Zbyšek ; Vališ, Martin (advisor) ; Mareš, Jan (referee) ; Hradílek, Pavel (referee)
Introduction Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease affecting the central nervous system. Although research on the diagnosis and treatment of this serious illness has made significant advances, the MS etiology remains unknown. Although there is still much to be found in the MS pathogenetic mechanisms, understanding the mechanisms of immune-mediated damage to the central nervous system (CNS) components of MS allows not only the introduction of new drugs that positively modulate inflammatory inflammation but also the understanding of immune- mediated diseases affecting the CNS in a broader sense. Methods The Ph.D. thesis is a general introduction followed by an annotated set of author's publications on proteomics, lymphocytic population in MS and disability. Study 1: Proteomic analysis of cerebrospinal fluid for relapsing-remitting multiple sclerosis and clinically isolated syndrome was conducted to find changes in the low molecular cerebrospinal fluid (CSF) segment and to determine what native peptides and how much they are in cerebrospinal fluid among patients with clinically isolated syndrome (CIS) and relapsing-MS (RR MS) compared to a healthy population. Study 2: Lymphocytes in the treatment with interferon beta-1b targeted individual...
Synchronization of circadian clock in rat during ontogenesis and in adulthood
Olejníková, Lucie ; Sumová, Alena (advisor) ; Šlamberová, Romana (referee) ; Mareš, Jan (referee)
The circadian system temporally controls behavioral and physiological processes in most organisms so that they change during the day and night with a period of about 24 h. It is an evolutionary adaptation to anticipate periodic changes in environment on the Earth. In mammals, the circadian system consists of the central pacemaker in the suprachiasmatic nuclei (SCN) of hypothalamus and of oscillators located in numerous peripheral organs and tissues. At the molecular level, the circadian clock is based on the rhythmic expression of so called clock genes. The ontogenetic development of the circadian system is a gradual process and the most important changes undergo during the late embryonic and early postnatal stage. Many behavioral, hormonal and metabolic signals provided by the mother are considered to be involved in circadian clock synchronization during early ontogenesis. The mechanisms of the entrainment are not fully known yet. The aim of this thesis was to study the development of the circadian clock and its entrainment via maternal signals and to compare the development of circadian rhythms in two model rat strains - Wistar rat and spontaneously hypertensive rat (SHR). Firstly, we described the ontogenetic maturation of the Wistar rat circadian clock in the colon from the fetal stage until...
Effective Tax Rates and Profit Shifting Around the World
Kraváček, Jan ; Janský, Petr (advisor) ; Mareš, Jan (referee)
This thesis aims to analyze the scope of profit shifting by U.S. multinational corporations using effective tax rates as a metric. Alternatively, unlike other academic literature on the subject, this work complements the analysis by utilizing also statutory coporate tax rate. The main contribution of the thesis is an econometric analysis of the most recent data provided by Bur- eau of Economic Analysis. It is shown that the scope of profit shifting is rising with gross income sensitivity to effective tax rates clearly increasing in the time span from 1983 till 2015. According to the panel data from this time span, one percentage point increase in effective tax rate would decrease the reported gross income in a low tax jurisdiction by 2.4 percent. Interestingly, an analogous analysis using statutory tax rates does not yield any statistically significant effect. Moreover, results show that the richer the country is, the lower its effective tax rate and the higher its statutory rate. These results indicate that the two metrics can have different implications. Furthermore, if some version of profit apportionment formula was applied on the profit of U.S. multinationals, a significant profit redistribution would take place. Gross income would oftentimes be attributed to developing coun- tries with a large share of...
Effect of expectations on civil-war and its recurrence
Kořánová, Barbora ; Gregor, Martin (advisor) ; Mareš, Jan (referee)
The goal of this thesis is to shed light on the efect of expectations on the civil war and its recurrence. We use a dataset that covers over 90 countries over the period of 1970-2014. First, we introduce proxy-variables of expectations about the future presence of civil war into an econometric model of occur- rence of civil conlict. Using the logistic regression, we ind that expectations have a signiicant inluence on the onset of civil conlict. Thereafter, we ex- amine the impact of these expectations in post-conlict situations, which is smaller but non-negligible. Subsequently, we compare the features of post- conlict countries, where civil war has repeated within 10 years and where it has not, via the Welch test. Finally, we describe conlict as a game with complete information and as a Bayesian game. In these we identify the role of expectations about opponent's action and the role of changes in payofs. JEL Classiication D74, C21, D84, C72 Keywords civil war, post-conlict, cross-section, noncoop- erative games, expectations Author's e-mail bara.koranova@seznam.cz Supervisor's e-mail gregor@fsv.cuni.cz
Optimalizace nakládání s kompostovatelným odpadem ve svozové oblasti města Pacov
Mareš, Jan
This diploma thesis is divided into two parts - theoretical and practical. The theoretical part summarizes the legal environment in this field, characteristics of selected types of waste, the possibility of their collection and methods for handling with them. Transition between the theoretical and the practical part consists of a block, which aims to familiarization with location of the town Pacov, create an overview and current status. The practical part is focused on the comparison of the current state of separation and collection of biodegradable waste with possible alternatives that would lead to improving the management of this waste and higher use of facility designated for that purpose - compost facility.
Business plan: self service car wash
Slabý, Adam ; Andera, Michal (advisor) ; Mareš, Jan (referee)
The objective of this diploma thesis is to form a business plan for a self service car wash. It analyzes the necessary resources, tests the viability, and calculates the financial performance of the project. The thesis is divided into two main parts. The first part theoretical, mainly describes the structure, requirements and purpose of a business plan, especially tools for market analysis, financial planning or financing options available for the proposed project. The second part practical, is composed of an actual business plan drawn up for a self-service car wash in Karlovy Vary.
Marketing analysis of Helveti s.r.o. (www.helveti.cz)
Kříčka, Martin ; Habrmanová, Blanka (advisor) ; Mareš, Jan (referee)
The aim of this thesis is to analyze the marketing tools of an e-commerce company, to evaluate them and to propose suggestions for improvement which will be implemented in the company strategy. The theoretical part describes the history of the Internet and its importance in the current business environment, the strategic procedures applied in online marketing and the description of individual marketing instruments. The practical part introduces the company, its products and its main competitors. Afterwards follows the analysis and comparison of the main online marketing tools and proposals for improvement which should be implemented in the marketing strategy are presented.
Analysis of the business model, web application.
Kubiš, Daniel ; Svobodová, Ivana (advisor) ; Mareš, Jan (referee)
The aim of the bachelor thesis was to analyze the business model of the web application to assess and design the MVP (minimum viable product). The aim of the bachelor thesis was to analyze the business model of the web application for assessment and design of a minimally viable product. The Web application has the ambition to become a global community platform that will be the standard for capturing, researching and preserving artifacts in a digitized form. Based on these goals, the bachelor thesis was divided into two theoretical and practical parts. In the theoretical part was defined the project, strategy and methodology that we will apply in the practical part. The Lean Canvas business model was used to meet the goal. With the description of nine complementary elements of the model, it will be possible to design a solution that could be implemented to create a minimum viable product. This conclusion was contributed by partial analyzes, with the main aim of knowing the targeted segment of users.

National Repository of Grey Literature : 108 records found   1 - 10nextend  jump to record:
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