National Repository of Grey Literature 8 records found  Search took 0.00 seconds. 
Making methodology of work with volunteers in the Diocesan Charity in České Budějovice
LANGOVÁ, Martina
The work deals with the methodology of work with volunteers in the Volunteer Centre of the Diocese Charity in České Budějovice. Firstly, the Volunteer Centre is characterized as a part of the Charity of the Czech Republic. The work deals with the volunteering in general, aiming at the evolution and characteristics of the volunteering in the Czech Republic, defining related terms, legislation, volunteers´ motivation and professionalization in the social area. Secondly, the work deals with the methodology of work with volunteers, its aims and methods. In addition, the ethical code is treated as an essential part of the work. The important part of the work is the concrete methodology of work with volunteers in the programme Bridges of Hope.
Prenatal diagnosis of the most frequent aneuploidies: development and current situation
Vintrová, Iva ; Langová, Martina (advisor) ; Polívková, Zdeňka (referee)
Prenatal diagnosis mainly focuses on revealing aneuploidies - the most frequent cause of mental and physical retardation in the childhood and perinatal death. Nowadays, fetal cells are obtained by invasive methods of prenatal diagnosis with some risk of spontaneous miscarriage. To eliminate those perils only pregnancies detected by screening as presenting high risk of aneuploidies are subjected to the cytogenetic and molecular-genetic methods. Powered by TCPDF (
Acquired chromosomal aberrationns in peripheral blood lymphocytes of patients with newly diagnosed cancer and healthy control individuals.
Vodenková, Soňa ; Polívková, Zdeňka (advisor) ; Langová, Martina (referee)
The majority of human cancers arise due to cells inabitily to maintain genomic stability. Cytogenetic changes (especially chromosomal aberrations) in peripheral blood lymphocytes which reflect not only the individual exposure to genotoxic factors, but also individual sensitivity to genotoxic effect and the tumor is late consequence to genotoxic effect. Summary epidemiological prospective studies over the last ten years have shown that increased level of chromosomal aberrations in peripheral blood lymphocytes is predictive of cancer risk. This thesis is focused on the detection of particular types of chromosomal damage in patients with choosed types of newly diagnosed cancers compared to healthy control persons. We cytogenetically analyzed 100 patients with colorectal cancer and 298 controls and 123 patients with breast cancer and 123 controls - healthy women. We compared the percentage of aberrant cells, the percentage of total aberrations, the percentages of chromatid and chromosome aberrations found in patients with both types of tumors and in controls and we verified the predictive value of chromosomal aberrations as a biomarker of cancer risk. In patients with colorectal cancer was statistically significantly increased only the level of chromatid aberrations (CHTA) (1,45±1,28) compared to...
Mutagenic and Antimutagenic Effect of Environmental Substances
Langová, Martina ; Vodička, Pavel (advisor) ; Sedmíková, Markéta (referee) ; Novotná, Božena (referee)
In the present study were used reference mutagens which effects mutagenic activity in prokaryotic and eukaryotic testing systems. Aflatoxin B1 (AFB1) is one of the most thoroughly studied and the well known mycotoxin with carcinogenic activity. 2-Amino-3-methylimidazol[4,5-f] quinoline (IQ) in isolated form has been used as another reference mutagen. These compounds are indirect acting genotoxins, i.e. need metabolic activation to exert genotoxic effect. As a third reference mutagen in the present study there has been chosen N-nitroso-N-methylurea (MNU) which is direct acting carcinogenic N-nitroso compound. The aim of the study was to investigate antimutagenic effects of ellagic acide (EA), resveratrol (RES), diallyl sulfide (DAS) and phenetyl isothiocyanate (PEITC) on the mutagenicity of the mutagens. The Ames test with Salmonella typhimurium TA98 and TA100 strains was used for the evaluation of antimutagenic effect of EA, RES, DAS and PEITC in vitro.
Cytogenetic methods in genotoxicology
Bártů, Linda ; Langová, Martina (referee) ; Daňková, Pavlína (advisor)
We are constantly exposed to a variety of factors which may be a cause of DNA mutations. The influence of mutagens of physical, chemical and biological origin is studied by genotoxicology. Ionic radiation is among the most common physical mutagens, benzene, vinylchloride or some drugs represent the chemical mutagens, while some viruses and may act as biological mutagens. The repair mechanisms of double strand breaks can be divided into those that require HRR-homologous sequences and those that may use of microhomologies consisting of a short DNA sequence (NHEJ). Both mechanisms can lead to aberrations of chromosomes, if they are not precise. Acquired chromosomal aberrations include translocation, common in cancer cells; deletion; or the production of acentric fragments, dicentrics and rings. Chromatid aberrations includes chromatid breaks and chromatide exchanges. There are various methods for detecting/examining such mutations and these can be categorised according to the phases of the cell cycle. The basic method is clasic Giemsa stain which reveals the most of aberrations except translocations and inversions and numeric abnormalities in metaphasic cells. Another way of testing mutagenicity is determining the rate of sister chromatide exchange; or the so called micronucleus test used to measure...
Utilization of Project Method in Teaching of Humanities at Secondary School
LANGOVÁ, Martina
The present bachelor thesis deals with project teaching and using the project method in teaching humanities. It is divided into two parts, theoretical and practical. The contents of theoretical part is a summary of available information, which I obtained from professional literature. It includes a brief historical development of project education not only in the Czech environment, terminological definition of basic concepts, preparation and implementation of project teaching a typology of projects. The thesis outlines the basic negatives and positives that come with project-based learning brings. The practical part deals with the design of a particular project, its verification and a description of its implementation.
The village school between the village and parish. School in Svatý Jan nad Malší in 1880 - 1945.
LANGOVÁ, Martina
The present work deals with the development of elementary school in Svatý Jan nad Malší in 1880 - 1945. The work is based next to the professional literature on archival sources deposited in the State District Archive in České Budějovice in the fund Archive of village Svatý Jan nad Malší (partially processed), the parish office of Svatý Jan nad Malší, Local School Board of Svatý Jan nad Malší, primary school in Svatý Jan nad Malší (unprocessed). The thesis is divided besides standard introduction and conclusion into six chapters. The first and the second one close to the village and parish of Svatý Jan nad Malší. The third chapter on the basis of literature describes the development of primary education in the Czech lands. The remaining three chapters then provide space for the school itself. The fourth chapter is devoted to the school building, the organization of the school year, celebrations, deals with the local council and school aids, the six chapter focuses on teachers and pupils. Part of the work is pictorial and text attachments.

See also: similar author names
1 LANGOVÁ, Marta
5 LANGOVÁ, Martina
1 Langová, Marie
4 Langová, Markéta
5 Langová, Michaela
1 Langová, Monika
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