National Repository of Grey Literature 10 records found  Search took 0.00 seconds. 
GENE EXPRESSION AND IMMUNOLOGICAL RESPONSE IN MICE EXPOSED TO ZnO NANOPARTICLES
Rössner ml., Pavel ; Vrbová, Kristýna ; Strapáčová, S. ; Rössnerová, Andrea ; Ambrož, Antonín ; Brzicová, Táňa ; Líbalová, Helena ; Javorková, Eliška ; Zajícová, Alena ; Holáň, Vladimír ; Kulich, P. ; Večeřa, Zbyněk ; Mikuška, Pavel ; Coufalík, Pavel ; Křůmal, Kamil ; Čapka, Lukáš ; Dočekal, Bohumil ; Šerý, Omar ; Machala, M. ; Topinka, Jan
We analyzed gene expression changes in the lungs and the immunological response in splenocytes of mice exposed by inhalation of ZnO nanoparticles - NP. Adult female ICR mice were treated for three days and three months, respectively. Analysis of differential expression in genes involved in oxidative stress was conducted using quantitative RT-PCR. The potential immunotoxic and immunomodulatory effects of ZnO NP were analyzed by phenotyping and cytokine production by splenocytes after three months exposure. Three days exposure resulted in down-regulation of GCLC, GSR, HMOX-1, NQO-1, NF-kB2, PTGS2 and TXNRD1 mRNA expression, three months exposure increased the expression of these genes. Three months exposure caused a significant decrease in the percentage of granulocytes in the spleen cells, and affected the production of IL-10 and IL-6 by lipopolysaccharide-stimulated leukocytes. In summary, our study revealed changes in the expression of genes involved in the oxidative stress response following acute ZnO NP exposure. Subchronic ZnO NP exposure induced immunomodulatory effects in the spleen.
Preparation of revitalization study for small water course
KULICH, Petr
The aim of this thesis is to prepare a design for the revitalization measures of Biřkovský stream including a design for polders "Karlovka and Niva". The designed measures should protect the village Biřkov from flash floods and enhance further increase of both water management and ecological stability of the basin. The solution is based on the assessment of hydrological, pedological, hydrogeological and vegetation docementation as well as the results of a detailed field survey of the area which is also reported in this thesis.
Dynamic Analysis of Track
Kulich, Pavel ; Salajka, Vlastislav (referee) ; Plášek, Otto (advisor)
The diploma thesis deals with analytical description of vehicle - track dynamic interface. There are described basic analytical models which are subsequently extended in order to get a more precise description of dynamic phenomena. The aim is to compile a model that faithfully describes the dynamic phenomena in the track. These new compiled models are qualitatively compared with data obtained by measuring in the track.
Single particle analysis of size-segregated aerosol in Prague city center
Marvanová, S. ; Skoupý, Radim ; Kulich, P. ; Bendl, J. ; Hovorka, J. ; Machala, M.
Particulate matter (PM) is omnipresent pollutant in the ambient air known to cause cardiovascular and respiratory diseases (WHO 2004). Recently, outdoor air pollution and particulate matter in outdoor air pollution were classified as carcinogenic to humans, Group 1 (IARC 2015). Especially, ambient PM of aerodynamic diameter < 100 nm, ultrafine particles, appears to be of great importance due to its high specific surface area and high number concentration (Hughes et al. 1998). Ultrafine particles also easily enter and are being transferred in organisms, and interact with cells and subcellular components (Oberdorster et al. 2005). As the evidence of ultrafine PM significance increased, size-fractionated PMs sampled by various cascade impactors have been employed into the toxicological studies on cell cultures or isolated cells, using the organic extracts of size-fractionated PMs (Topinka et al. 2013, Topinka et al. 2015) or directly the size-fractionated particles (Becker et al. 2003, Ramgolam et al. 2009, Reibman et al. 2002, Loxham et al. 2013, Jalava et al. 2006, Thomson et al. 2015, Jalava et al. 2015). The aim of this study was to evaluate shape and composition of size-segregated aerosol particles, sampled by high volume cascade impactor, using electron microscopy and energy dispersive X-ray spectroscopy (EDX).
Design of Residential Ship
Kulich, Petr ; Zdařil, Zdeněk (referee) ; Zvonek, Miroslav (advisor)
Theme of this diploma thesis is design of residental yacht, focused on applying of modern technologies with aim to make the work flow more efective. I would like to achieve better results in question of fuel saving and ecology, by using hybrid engine systém and solar power. My next aim was interlacing of construction and ergonomic parameters in the way to achieve comfort and save enviroment for the travelers.
Design of Speaker
Kulich, Petr ; Sládek, Josef (referee) ; Zvonek, Miroslav (advisor)
Subject of this bachelor thesis is design of speakers. I aimed at sound system type 2.1, two satelite speakers and subwoofer. Main point of this design is simple portability and adjustability of speakers. With that corresponds used technology and ergonomic parameters. I took into account price and interier variability.
Vsetin - Velke Karlovice Railway Track Refurbishment (section between km 17,000 - 19,950 km) Including Track Laying Technology
Kulich, Pavel ; Pokorný, Ondřej (referee) ; Říha, Tomáš (advisor)
Bachelor´s thesis deals with design of permanent way and track geometry parameters of the selected section of Vsetín – Velké Karlovice railway track. The design should be considered primarily on existing objects such as railway crossings, culverts, railway stops, bridges , etc. Thesis includes restoration of drainage and track laying technology. It should be noted, that all proposed adjustments are designed according to current regulations and legislation.
The issue of the storages of nuclear waste in the Czech Republic and their impact on the environment - influence analysis on the example of the selected locality.
KULICH, Petr
The thesis deals with topical situation concerning deep geological repository in the Czech Republic and the effect on the environment is analyzed within the particular location Březový potok near the municipality Pačejov in Pilsen region. The thesis concerns with the potential impact on the landscape, agricultural production and inhabitants.
Analysis of the E-Commerce Website and Realization of Chosen Recommendations
Kulich, Petr ; Stříteský, Václav (advisor) ; Štědroň, Bohumír (referee)
The aim of this thesis consists of defining a set of recommendations that should lead to more successful e-commerce website of EuroCup Agency s.r.o. The aim also consists of creating a schedule of their realization, setting of the complete realization goals and realizing of the recommendations that belong to the first phase. The thesis is based on theoretical presentation of possible steps that could be realized for improving e-shops' successfulness, and on extensive analysis of the monitored e-commerce website. This analysis is focused on the company's market, target segments and competitors, company's sales, offline conversion rate, statistics measured by Google Analytics tool, and usability of the e-commerce website.
Metody zvyšování konverzního poměru elektronického obchodu
Kulich, Petr ; Stříteský, Václav (advisor) ; Štědroň, Bohumír (referee)
Bakalářská práce se zabývá komplexním pohledem na konverzní poměr - ukazatel, jehož využití je nezbytné pro správné vyhodnocování úspěšnosti na intenetu. Teoretická část poskytuje obecné informace o konverzích a konverzním poměru, jejich klasifikaci, způsobech a nástrojích pro jeho měření. Dále také popisuje celou řadu oblastí, jejichž zlepšení často vede k několikanásobnému zvýšení konverzního poměru. Poznatky z této části byly aplikovány na konkrétní situaci společnosti EuroCup Agency s.r.o. a jejího internetového obchodu. Tato společnost se zabývá prodejem sportovních trofejí a upomínkových předmětů. Výstupem bakalářské práce je sada doporučení pro zvýšení konverzního poměru elektronického obchodu. Tato doporučení vychází z provedené analýzy současného stavu.

See also: similar author names
6 KULICH, Petr
2 Kulich, Pavel
6 Kulich, Petr
Interested in being notified about new results for this query?
Subscribe to the RSS feed.