National Repository of Grey Literature 206 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
The Fight for the Freedom of Speech: Baden and German Liberalism in the 1830s
Návojová, Kateřina ; Kučera, Rudolf (advisor) ; Emler, David (referee)
This master thesis examines the political and particular media situation in 1832, with the stress on spreading the liberal ideas and their attempt to influence the public via one typical German journal for this period. Over six months, there was an extraordinary situation in Baden, when the censorship was restricted and suddenly there arose, for this period, unexpected possibilities for journalists. As a reaction to reduction of censorship, the journal Der Freisinnige was established. Although its existence was short-lived, manifestation of liberal values and reflection of contemporary opinions is evident. This journal was more important and powerful than any other because of the cooperation with one of the main initiators of liberalism, Karl von Rotteck, who was also active in politics. This connection of two roles was very powerful. Freedom of speech, understood as one of the major liberal demands, allowed the practical promotion of liberal ideas among citizens. This case study pays attention to this particular year, within the political inclinations and tendencies over the period 1815-1832 of the Grand Duchy of Baden and former German Confederation. There were clear connections to the events in the first third of the nineteen century, that made the short-time fall of censorship happen. At the...
GC analysis of drugs with utilization of ionic liquid as a stationary phase I
Bärová, Karolína ; Kastner, Petr (advisor) ; Kučera, Radim (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Supervisor: PharmDr. Petr Kastner, Ph.D. Student: Karolína Bärová Title of Thesis: GC analysis of drugs with utilization of ionic liquid as a stationary phase I In this thesis, we focused on testing of three commercially obtainable columns with ionic liquids as stationary phases, which we tested on a model sample of ibuprofen and its four pharmacopoeial impurities after derivatization by alkylchloroformates. The results obtained on these columns were compared to results obtained on column with conventional nonpolar stationary phase. Furthermore, we tried to describe and explain retention mechanisms, which were important in these separations, we also tried to optimize methods for our individual columns and extract our derivatives into a nonpolar phase, with the view to diminishing the harmful effect of samples on columns. We appraise the results obtained on ionic liquid stationary phases and on a nonpolar stationary phase as quite comparable. The analysis of our derived samples can be performed on all tested ionic liquid columns and the analysis can be optimized for all of them. Apart from the change in selectivity on the most polar stationary phase, we did not notice any great...
Nanofiltration
Heidrová, Hana ; Kučera, Radim (advisor) ; Holas, Ondřej (referee)
Charles University, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Nanofiltration Diploma thesis Candidate: Hana Heidrová Supervisor: doc. PharmDr. Radim Kučera, Ph.D. Consultant: PharmDr. Tomáš Holas, Ph.D. Nanofiltration is a pressure-driven membrane process which is characterized by using semipermeable membranes with approximately 1 nm pores. This method is used abundantly for the separation of substances with low molecular weight. It is used for example in the process of product isolation in pharmaceutical industry. This diploma thesis is focused on the description of the behaviour of three commercially produced nanofiltration membranes and also on testing of their potential use in the production of ergot alkaloids. The theoretical part is focused especially on the description of pressure-driven membrane processes, the use of nanofiltration in various areas and also on current and historical use of ergot alkaloids in therapy and on the description of their properties. The practical part is oriented particularly on examination of effect of various experimental parameters on the retention of selected ergot alkaloids (primarily of lysergic and isolysergic acid). The results are compared and critically analysed. Keywords: pressure-driven...
GC analysis of drugs using ionic liquid as stationary phase II
Hungerová, Lenka ; Kastner, Petr (advisor) ; Kučera, Radim (referee)
Charles university in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical chemistry and Pharmaceutical analysis Supervisor: PharmDr. Petr Kastner, Ph.D. Student: Lenka Hungerová Title of thesis: GC analysis of drugs using ionic liquid as a stationary phase II This thesis dealt with analysis of ibuprofen and its four pharmacopoeial impurities samples after derivatization by alkylchloroformates by gas chromatography (GC). The thesis builds on a thesis by Karolína Bärová (2018), who tested these samples on one column with a nonpolar stationary phase and on three columns with ionic liquid as a polar stationary phase. Three other columns with ionic liquids were used in this thesis, which showed higher polarity than the columns used by K. Bärová. There was an effort to describe the retention mechanisms, that were manifested here, and to optimize the conditions of the method on all the three columns. Following the previous experiments other options for improvement of the extraction yield of the derivatives into a nonpolar solvent were tested. The results indicate that all the three columns with ionic liquid as stationary phase can be used for analysis of these samples. The conditions of the method were optimized enough on all the columns. The extraction yield into the nonpolar...
Factors which affect the purification and stability bioconjugates azaftalocyanines
Cichý, Jakub ; Kučera, Radim (advisor) ; Pilařová, Pavla (referee)
Rigorous thesis Factors which affect the purification and stability bioconjugates azaftalocyanines Mgr. Jakub Cichý Charles University, Faculty of Pharmacy in Hradci Králové, Department of Pharmaceutical chemistry and pharmaceutical analysis This work continues in diploma thesis Purification azaphthalocyanines bioconjugates using SPE. It deals with the stability of molecular probes (i.e. "mono" and "dual- labeled") after dilution and storage in a given time period (fridge/freezer). We focused on the content changes of free oligonucleotide chains and probes containing azaphthalocyanine dyes using HPLC with detection at 260 and 673 nm, at following time intervals 0 h, 14 h, 13 days and 33 days. We found that molecular AzaPc probes were stable without significant changes in their content and purity even after a month of storage. The biggest influence on the purity of the azaphthalocyanine bioconjugates had the evaporation metod of the mobile phase from the sample after the purification step. Furthermore, we studied the posibility of purification of the "dual-labeled" probes containing AzaPc by SPE. Unfortunatly, the result showed that the examined SPE cartridges were unable to separate successfully the "mono-labeled" the"dual-labeled" probes from each other. Nevertheless, the phenyl column DSC-Ph (500...
Assessment of the suitability of the site for the location of the underground\nof SNF and RAW repository in terms of long-term safety - Horka site
Havlová, V. ; Pertoldová, J. ; Bukovská, Z. ; Hroch, T. ; Štědrá, V. ; Uhlík, J. ; Říha, J. ; Červinka, R. ; Baier, J. ; Buriánek, D. ; Černý, M. ; Dudková, I. ; Dušek, K. ; Franěk, J. ; Gondolli, J. ; Hokr, M. ; Holeček, J. ; Jankovec, J. ; Jelének, J. ; Jelínek, J. ; Kachlíková, R. ; Kaláb, Zdeněk ; Klajmon, M. ; Kolomá, K. ; Kouřil, M. ; Královcová, J. ; Kučera, R. ; Kunceová, E. ; Maryška, J. ; Milický, M. ; Nývlt, D. ; Ondra, P. ; Pacherová, P. ; Polák, M. ; Rapprich, V. ; Rukavičková, L. ; Steinová, J. ; Svoboda, J. ; Šír, P. ; Švagera, O. ; Vašíček, R. ; Vavro, Martin ; Vopálka, D. ; Zeman, J. ; Zeman, O.
This report summarises outline of a report for evaluation of the sites‘ suitability for the emplacement of a deep geological repository on the basis of the archive information and the geological survey conducted from surface.\nSites are evaluated according to the following criterion categories\n1. Geological characteristics of the site\n2. Hydrogeologic characteristics of the site\n3. Transport characteristics of the the site\n4. Site stability\n5. Factors, increasing probability of human intrusion into the site\n6. Acceptability of enginnered barrier properties under site conditions
Assessment of the suitability of the site for the location of the SNF and RAW deep geological repository in terms of long-term safety - Dukovany - West site\n(EDU-Z).
Havlová, V. ; Pertoldová, J. ; Bukovská, Z. ; Hroch, T. ; Štědrá, V. ; Jankovec, J. ; Říha, J. ; Červinka, R. ; Černý, M. ; Dudková, A. ; Dušek, K. ; Franěk, J. ; Gondolli, J. ; Gvoždík, L. ; Hokr, M. ; Holeček, J. ; Hrdličková, K. ; Jelének, J. ; Jelínek, J. ; Kachlíková, R. ; Kaláb, Zdeněk ; Klajmon, M. ; Kolomá, K. ; Královcová, J. ; Kouřil, M. ; Kryštofová, E. ; Kučera, R. ; Kunceová, E. ; Maryška, J. ; Milický, M. ; Nývlt, D. ; Ondra, P. ; Pacherová, P. ; Polák, M. ; Rapprich, V. ; Rukavičková, L. ; Sedláčková, I. ; Vašíček, R. ; Vavro, Martin ; Vopálka, D. ; Uhlík, J. ; Zeman, J. ; Zeman, O.
This report summarises outline of a report for evaluation of the sites suitability for the emplacement of a deep geological repository on the basis of the archive information and the geological survey conducted from surface.\nSites are evaluated according to the following criterion categories\n1. Geological characteristics of the site\n2. Hydrogeologic characteristics of the site\n3. Transport characteristics of the the site\n4. Site stability\n5. Factors, increasing probability of human intrusion into the site\n6. Acceptability of enginnered barrier properties under site conditions
Assessment of the suitability of the site for the location of the deep-water repository and RAW repository in terms of long-term safety - Čihadlo site
Havlová, V. ; Pertoldová, J. ; Bukovská, Z. ; Hroch, T. ; Štědrá, V. ; Polák, M. ; Říha, J. ; Červinka, R. ; Černý, M. ; Dudíková Schulmannová, B. ; Dudková, A. ; Dušek, K. ; Franěk, J. ; Gondolli, J. ; Gvoždík, L. ; Hokr, M. ; Holeček, J. ; Jankovec, J. ; Jelének, J. ; Jelínek, J. ; Kachlíková, R. ; Kaláb, Zdeněk ; Klajmon, M. ; Klomínský, J. ; Kolomá, K. ; Kouřil, M. ; Královcová, J. ; Kučera, R. ; Kunceová, E. ; Lednická, Markéta ; Maryška, J. ; Milický, M. ; Nývlt, D. ; Ondra, P. ; Polák, M. ; Rapprich, V. ; Rukavičková, L. ; Steinová, J. ; Svoboda, J. ; Šír, P. ; Švagera, O. ; Uhlík, J. ; Vašíček, R. ; Vavro, Martin ; Verner, K. ; Vopálka, D. ; Zeman, J. ; Zeman, O.
This report summarises outline of a report for evaluation of the sites suitability for the emplacement of a deep geological repository on the basis of the archive information and the geological survey conducted from surface.\nSites are evaluated according to the following criterion categories\n1. Geological characteristics of the site\n2. Hydrogeologic characteristics of the site\n3. Transport characteristics of the the site\n4. Site stability\n5. Factors, increasing probability of human intrusion into the site\n6. Acceptability of enginnered barrier properties under site conditions
Evaluation of the suitability of the site for the location of the deep-water repository and RAW repository in terms of long-term safety - Čertovka site.
Havlová, V. ; Pertoldová, J. ; Bukovská, Z. ; Hroch, T. ; Štědrá, V. ; Černý, M. ; Říha, J. ; Červinka, R. ; Baier, J. ; Dudková, I. ; Dušek, K. ; Franěk, J. ; Gondolli, J. ; Gvoždík, L. ; Holeček, J. ; Hokr, M. ; Jankovec, J. ; Jelének, J. ; Jelínek, J. ; Kachlíková, R. ; Kaláb, Zdeněk ; Klajmon, M. ; Kolomá, K. ; Kouřil, M. ; Královcová, J. ; Kučera, R. ; Kunceová, E. ; Kůrková, I. ; Maryška, J. ; Milický, M. ; Nývlt, D. ; Ondra, P. ; Pacherová, P. ; Polák, M. ; Rapprich, V. ; Rukavičková, L. ; Steinová, J. ; Svoboda, J. ; Šír, P. ; Švagera, O. ; Vašíček, R. ; Vavro, Martin ; Vopálka, D. ; Uhlík, J. ; Zeman, J. ; Zeman, O. ; Žáček, V.
This report summarizes the data available from the Čertovka site and evaluates the site according to criteria derived by RAWRA staff from SÚJB requirements (Decree No. 378/2016 Coll. On the Location of Nuclear Equipment) and IAEA (NS-R-3 rev.1 Site Evaluation for Nuclear IAEA 2016; SSG-14 Geological Disposal Facilities for Radioactive Waste, IAEA 2011b) on site characteristics that have an impact on long-term DGR security (MP22 v3, Vokál et al. 2017). Sites are ranked according to the following categories of criteria:\n1) Geological characteristics of the site\n2) Hydrogeological characteristics of the site\n3) Site transport characteristics\n4) Site stability\n5) Factors increasing the probability of human intrusion into the site\n6) Compatibility of rock mass properties with engineering barriers
Assessment of the suitability of the site for the location of the VJP and RAW deep geological repository in terms of long-term safety - locality Březový Potok
Havlová, V. ; Pertoldová, J. ; Bukovská, Z. ; Hroch, T. ; Štědrá, V. ; Baier, J. ; Říha, J. ; Červinka, R. ; Černý, M. ; Dudková, I. ; Dušek, K. ; Franěk, J. ; Gondolli, J. ; Gvoždík, L. ; Hokr, M. ; Holeček, J. ; Jankovec, J. ; Jelínek, J. ; Kachlíková, R. ; Kaláb, Zdeněk ; Klajmon, M. ; Kolomá, K. ; Kouřil, M. ; Královcová, J. ; Kučera, R. ; Kunceová, E. ; Maryška, J. ; Milický, M. ; Nývlt, D. ; Ondra, P. ; Polák, M. ; Rapprich, V. ; Rukavičková, L. ; Soejono, I. ; Steinová, J. ; Svoboda, J. ; Šír, P. ; Švagera, O. ; Uhlík, J. ; Vašíček, R. ; Vopálka, D. ; Zeman, J. ; Zeman, O.
This report summarizes the available data from the Březový potok site and evaluates the site according to criteria derived by RAWRA staff from SÚJB requirements (Decree No. 378/2016 Coll. On the Location of Nuclear Installations) and IAEA (NS-R-3 rev.1 Site Evaluation for Nuclear Installations) Safety Requirements, IAEA 2016; SSG-14 Geological Disposal Facilities for Radioactive Waste, IAEA 2011b) on site characteristics that affect long-term DGR security (MP 22 version 3, Vokál et al. 2017). Sites are ranked according to the following categories of criteria:\n1) Geological characteristics of the site\n2) Hydrogeological characteristics of the site\n3) Site transport characteristics\n4) Site stability\n5) Factors increasing the probability of human intrusion into the site\n6) Compatibility of rock mass properties with engineering barriers.

National Repository of Grey Literature : 206 records found   1 - 10nextend  jump to record:
See also: similar author names
1 KUČERA, Richard
5 Kučera, Radek
3 Kučera, Radim
2 Kučera, Roman
2 Kučera, Rudolf
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