National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Cell-penetrating peptides - pitfall of endosomal entrapment and its overcoming
Kadlecová, Julie ; Váňová, Jana (advisor) ; Holá, Dana (referee)
The aim of the thesis is to introduce cell penetrating peptides as a potential way of transporting cargo into cells. Their ability to penetrate cell membranes with attached cargo is demonstrated. The structure and sequences of these peptides, on which their unique property to penetrate through the cell membranes is built, are described with respect to the different modes of transport. The difficulty of internalizing these CPPs via endocytosis is the frequent trapping of peptide with attached cargo in the endosome. If this occurs, the endosome content is degraded and the CPP with attached cargo is not released into the cytosol or nucleus, their target site. This work focuses on creative options, how to make release from endosome easier for CPPs with attached cargo. The introduction of such modified CPPs would accelerate their use in clinical medicine to enable the treatment of diseases such as cancer or antibiotic- resistant diseases.
The possibilities of school and local comunity in the system of prevention deliquent behaviour tean-agers.
Kadlecová, Julie ; Koťa, Jaroslav (advisor) ; Komárková, Tereza (referee)
This thesis deals with the prevention of youth delinquency in the Czech Republic. The theoretical basis is characteristic of individual in adolescence and system description prevention of youth delinquency. The section devoted to adolescence describes individuals aged 15-18years, describes the psychological and developmental characteristics. An Attention is paid to the causes of youth delinquency. The prevention part explains the theoretical foundations on which is a system of prevention in the Czech Republic. This thesis describes the system and highlights the continuity and consistency between the elements of the system. Special attention is given to prevention at the school and local community. The empirical part is devoted to identifying the opinions and attitudes of the respondents in the area of prevention. The survey used two methods of qualitative research - questionnaires and brainstorming. Keywords youth, adolescence, delinquency, prevention, public institutions, private institutions, schools, local location, street work, Ide - threshold institution, interview, brainstorming

See also: similar author names
26 KADLECOVÁ, Jana
1 KADLECOVÁ, Jaroslava
1 KADLECOVÁ, Jolana
26 Kadlecová, Jana
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