National Repository of Grey Literature 19 records found  1 - 10next  jump to record: Search took 0.00 seconds. 
Cellular senescence and ageing-associated diseases
Antoš, Šimon ; Hodný, Zdeněk (advisor) ; Horníková, Daniela (referee)
In the last years more evidence supports the role of cellular senescence in ageing-associated diseases. Cellular senescence plays a role in these diseases on multiple levels and often directly supports their pathogenesis. The goal of this bachelor thesis is to summarize latest knowledge regarding the mechanism and the efect cellular senescence has in ageing-associated diseases, namely cancer, atherosclerosis, osteoarthritis, neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and multiple sclerosis, obesity and diabetes mellitus type two.
The role of desmin in a heart
Šeovićová, Maja ; Horníková, Daniela (advisor) ; Vegrichtová, Markéta (referee)
Desmin forms a muscle specific intermediate filament which participates in a formation of a dynamic intracellular network that links contractile apparatus with a sarcolemma, mitochondria and it provides a communication with a cell nucleus. This network serves to maintain morphological and functional aspects of muscle cells and cell organelles during a muscle contraction. Mutation in a desmin or an absence of desmin is causing a serious disease called desminopathy, which belongs among a group of myofibrillar myopathies. This disease manifests itself in all muscle types, however first observable defects occur in cardiac mitochondria, thus heart is a first organ manifesting symptoms of this disease. The purpose of this thesis was to summarize a current knowledge about physiological and molecular mechanisms that involved in a formation of intracellular desmin network and about patho-physiological states of desminopathies. Key words: desmin, intermediate filaments, heart, desminopathy, cardiomyopathy
Neurophysiology of the urinary system after spinal cord injury.
Štěpánková, Kateřina ; Machová Urdzíková, Lucia (advisor) ; Horníková, Daniela (referee)
Spinal cord injury (SCI) is a devastating condition that is a result of trauma generated by traffic accident, violence or falling. However, SCI may not only be caused by trauma, but also by other diseases such as - virus infection, tumors etc.. Any SCI affects the ability of the spinal cord to transmit and receive information and their further processesing. The spinal cord injury itself is followed by other complications that seriously impair the quality of life of the patients. One of the main problems is the dysfunction of the urinary system, which then does not work properly, thereby make patient's life dificult on the health and social side. The aim of this thesis is to summarize pathophysiological consequences of SCI on urinary tract dysfunction. Keywords: neurophysiology, spinal cord injury, paraplegia, urinary tract
Peroxisomes and their role in energetic metabolism of the heart
Čejková, Denisa ; Kolář, David (advisor) ; Horníková, Daniela (referee)
Peroxisomes are small eucaryotic organelles, mainly known for their ability to create and break down hydrogen peroxide. However their enzymes play other significant roles, they participate in beta-oxidation of fatty acids with very long or branched chains, through alpha-oxidation they enable to process molecules that cannot go through beta- oxidation cycle, they also participate in early steps of synthesis of ether-lipid or bile acides. Above mentioned aspects make peroxisomes potentionally interesting for their possible influence on heart muscle metabolism, that is dependent on oxidative degradation of fatty acids, although not very much is known about this issue. The thesis focuses on biogenesis and function of peroxisomes, but also on their possible role in heart muscle metabolism.
Energy metabolism and apoptotsis markers in cold heart aclimated rat.
Pospíšilová, Barbora ; Horníková, Daniela (advisor) ; Knytl, Martin (referee)
Cold adaptation and her effects has been known for many decates. Positive or negative impact depends especially on its length and strength. The lower temperature can very often cause the stress for organism. On the other hand in expreriment with long-term adapatation were found positive consequences on cardiovascular system. We found the lack of studies devoted to the energy metabolism and apoptosis in heart tissue during long-term cold adaptation. In this work we used a model with milder conditions of the adaptation (10žC±1), so there wouldn't be damage of the experimental animals. We compared the resuls betwen control, cold and regressive group of rats. In this expreriment we used methods of electrophoresis and Western blot. The target of the work was found if we can find any differences betwen chosen HIF targeted genes. The next goal was to detect the differences betwen chosen pro-apoptotic and anti-apoptotic markers. Keywords: cold adaptation, heart, energetic metabolism, HIF, apoptosis
The role of SGK1 in heart
Havlíková, Nikola ; Horníková, Daniela (advisor) ; Mančíková, Andrea (referee)
Serum and glucocorticoid-regulated kinase 1 (SGK1) is an enzyme which is encoded by the sgk1 gene. This is a dimer. Generally, SGK1 belongs into the protein kinases, but its structure is somehow different from the other protein kinases, especially in the reaction center, which is related to its activity. SGK1 belongs to the subfamily of serine/threonine kinases. This kinase is activated by insulin or growth factors via phosphatidylinositol-3-kinase (PI3K) and mammalian rapamycin mTORC2. SGK1 plays an important role in inflammatory processes, the proliferation and apoptosis. In heart it helps to increase the abundance of proteins, which has affect on the morphology of ion channels and Na+ /K+ -ATPase. The sgk1 gene plays an important role in cellular stress response. This kinase activates potassium, sodium, chloride and calcium channels, which suggests about the involvement in the regulation of processes such as the cell survival, neuronal excitability and renal sodium excretion. Currently, the most discussed roles of SGK1 are in the heart, kidneys, brain, lungs and gastrointestinal tract. In recent years, it was found that SGK1 has different expression and regulation during the developmental stages and pathological conditions such as hypertension, diabetic neuropathy, ischemic trauma and...

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