National Repository of Grey Literature 4 records found  Search took 0.00 seconds. 
Regulation of the DNA damage response by R2TP mediated MRN complex assembly and control of 53BP1 localisation.
Von Morgen, Patrick ; Hořejší, Zuzana (advisor) ; Bártová, Eva (referee) ; Kleibl, Zdeněk (referee)
DNA double strand breaks are the most dangerous type of DNA damage. The MRN complex and 53BP1 have essential functions in the repair of DNA double strand breaks and are therefore important for maintaining genomic stability and preventing cancer. DNA double strand breaks are repaired by two main mechanisms - homologous recombination and non- homologous end joining. The MRN complex senses DNA double strand breaks and activates a cascade of posttranslational modifications that activates and recruits other effector proteins. In addition MRN mediated resection is important for removing adducts in non-homologous end joining and creating single stranded DNA required for homologous recombination. 53BP1 is recruited to DNA double strand breaks by site specific ubiquitinations and inhibits DNA resection, thereby promoting non-homologous end joining at the expense of homologous recombination. In this thesis we show that MRE11 binds to the R2TP chaperone complex through a CK2 mediated phosphorylation. Knockdown of R2TP or mutating the MRE11 binding site leads to decreased MRE11 levels and impaired DNA repair. Similar phenotype has been observed in cells from patients with ataxia-telangiectasia-like disorder (ATLD), containing MRE11 deletion mutation which is missing the R2TP complex binding site. Based on R2TP...
Corruption rate and economic performance
Hořejší, Zuzana ; Soukupová, Jana (advisor) ; Džbánková, Zuzana (referee)
This Bachelor´s thesis is focused on a level of corruption and economic influence in selected countries of EU. Theoretical part is focused on a description of the term of corruption, types of corruption, forms of measuring corruption and last but not least causes and consequences of corruption. The basis of the practical part is a regression and correlation analysis which I apply to observed indicators in selected countries of EU. These observed indicators are CPI, GDP in PPP, and Legatum Prosperity Index. The aim of my thesis is to find out if there is a relation among these indicators and then how strong is a dependency among them.
Canisterapie in Preschool Setting
The school leaving thesis is elaborated in order to make a connection of canistherapy with the environment of kindergartens. The thesis is devided into two main parts. The theoretical part concerns the development of an individual and the problems of canistherapy and its methods. The practical part reveals a possible connection of canistherapy effects and the environemnt of kindergartens. The aim of the practical part is to find out how the teachers are informed about this term.

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4 HOŘEJŠÍ, Zuzana
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