National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Regional flow and number of microembolisms in the common carotid artery at different levels of hemodynamics controlled by VA-ECMO.
Janák, David ; Kittnar, Otomar (advisor) ; Danzig, Vilém (referee) ; Bešík, Josef (referee)
Extracorporeal membrane oxygenation (ECMO) is a method that allows extracorporeal life support in potentially reversible life-threatening conditions affecting the heart or lungs which are refractory to conventional treatment. Depending on the parameters of its setting, this method affects the haemodynamics of the cardiovascular system and the perfusion of the target organ. From the point of view of its character, the necessity for invasive application, and the function thereof in the conditions of the cardiovascular system, ECMO is regarded as a risky method accompanied by a number of complications. Among the critical complications are thromboembolic complications affecting the central nervous system (CNS) and haemorrhagic complications. The goal of this paper is to present and verify the prerequisites for the formation of periprocedural embolisms affecting the CNS and to evaluate the regional haemodynamics of the CNS. This is done by analysing the presence of embolisms and by analysing the parameters of blood flow rates in the right common carotid artery (arteria carotis communis-ACC) and the corresponding oxygenation of the brain tissue during various flow rate parameters generated by the ECMO support on induced heart failure in a biological porcine model. In the first section of the paper, 8...
Tolerance to acute ischemia in hypertrophic myocardium
Bešík, Josef ; Pirk, Jan (advisor) ; Šamánek, Milan (referee) ; Herget, Jan (referee)
Background: The degree of ischemic injury of the heart muscle depends not only on the intensity and duration of the ischemic insult, but also on the cardiac tolerance to oxygen deprivation. Cardiac tolerance to ischemia changes significantly during ontogenetic development neonates are more resistant to ischemia then adults. Moreover, cardiac tolerance to ischemia/reperfusion injury in adults is sex-dependent males are less tolerant than females. Individually the tolerance to ischemia decreases in certain pathological conditions, particularly in heart muscle hypertrophy. Aim: 1. The aim of this study was to answer the question whether the degree of tolerance to oxygen deprivation in hearts of spontaneously hypertensive rats (SHR) is sex-dependent and to verify the hypothesis whether cardiac tolerance of the normal neonatal heart differs from that of hypertensive rats. 2. To determine whether a higher resistence of the female hypertrophied myocardium to ischemia/reperfusion injury can be seen in clinical medicine. (...) Conclusions: We can conclude, that male and female hearts differ significantly in many parameters. Detailed mechanisms of these differences are still unknown but it is clear that they are so important that they deserve serious consideration in clinical practice and in the search for proper...

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