National Repository of Grey Literature 5 records found  Search took 0.00 seconds. 
Effect of biguanides on liver cells metabolism
Švecová, Eliška ; Kalous, Martin (advisor) ; Flachs, Pavel (referee) ; Hansíková, Hana (referee)
The extract from the plant Galega officinalis containing the guanidine derivative galegin has been used in the treatment of diabetes-associated complications since middle ages. Nevertheless, the positive effects of the treatment were often overweight by the adverse side effects. Some sixty years ago guanidin was replaced by the less toxic synthetic biguanide derivatives - metformin, phenphormin and buformin, the latter two being withdrawn due to the unacceptable risk of fatal lactate acidosis. Metformin is still widely used antidiabetics and belongs to the first choice drugs in the treatment of type 2 diabetes. Phenphormin is now gaining renewed attention with regard to its antineoplastic properties. Despite its long-term clinical use the mechanism of biguanides action is not fully understood yet. At present it is generally accepted that the core of its antihyperglycemic effect lays in the inhibition of hepatic gluconeogenesis. In contrast, there is less consensus regarding the particular metabolic pathway or target that are responsible for the metformin-induced attenuation of gluconeogenesis. For a long time, a hot candidate for metformin target in the cell was AMP-activated kinase (AMPK) but the metformin effect was proved also in mice carrying the dominant negative mutation of AMPK α subunit. Quite...
Effect of biguanides on liver cells metabolism
Švecová, Eliška
The extract from the plant Galega officinalis containing the guanidine derivative galegin has been used in the treatment of diabetes-associated complications since middle ages. Nevertheless, the positive effects of the treatment were often overweight by the adverse side effects. Some sixty years ago guanidin was replaced by the less toxic synthetic biguanide derivatives - metformin, phenformin and buformin, the latter two being withdrawn due to the unacceptable risk of fatal lactate acidosis. Metformin is still widely used antidiabetics and belongs to the first choice drugs in the treatment of type 2 diabetes. Phenformin is now gaining renewed attention with regard to its antineoplastic properties. Despite its long-term clinical use the mechanism of biguanides action is not fully understood yet. At present it is generally accepted that the core of its antihyperglycemic effect lays in the inhibition of hepatic gluconeogenesis. In contrast, there is less consensus regarding the particular metabolic pathway or target that are responsible for the metformin-induced attenuation of gluconeogenesis. For a long time, a hot candidate for metformin target in the cell was AMPK (AMP-activated kinase) but the metformin effect was proved also in mice carrying the dominant negative mutation of AMPK α subunit....
Effective complementary business of school canteens
Švecová, Eliška ; Svoboda, Petr (advisor) ; Všetečková, Helena (referee)
TITLE: Effective complementary business of school canteens AUTHOR: Eliška Švecová DEPARTMENT: School Management Centre SUPERVISOR: Ing. Petr Svoboda Ph.D. ABSTRACT: The main activity of school dining services is to provide catering for children and students, based on the Education Act and in accordance with the regulations on school dining. An additional activity is to provide catering services for other members of the local community. These additional activities enable school dining services to maintain their effectiveness in periods of falling birth rates and hence falling student numbers, as well as in more favourable times. The key objectives of this work are to gather basic information about school dining and the issues involved in additional catering services; to analyse the current situation in terms of declining student numbers; and, using research questionnaires, to explore the most critical factors impacting additional catering activities. The work is composed of two parts - the first is theoretical, and the second research-based. The theoretical section presents basic information about legislature on school catering, and examines the role of school dining and the issues concerned. The focus of the research component of this work is to analyse the data gathered through primary research, which has...
Analysis of the expert opinions on the business valuation
Švecová, Eliška ; Mařík, Miloš (advisor) ; Krch, Přemysl (referee)
This thesis is focused on analysis of expert opinions on the business valuation. Its goal is to identify the most serious mistakes in expert opinions and how to prevent them. The analysis is processed using preselected criteria. Totally twenty-two expert opinions are analyzed. The conclusion is a quantitative summary of the results of analysis of expertise, as well as pointing out the most common shortcomings and proposals for their elimination.
Algerian war
Švecová, Eliška ; Veselý, Zdeněk (advisor) ; Eichler, Jan (referee)
This thesis deals with the circumstances leading to the decolonization of Algeria. The aim of the thesis is to analyze French-Algerian relations during the Algerian war, especially to determine the specific features of Algeria and its importance for France. Another aim is the analysis of two opposite groups: the French nationalist organization Secret Army Organization whose objective was maintenance of French Algeria, and National Liberation Front which, in contrary, desired to gain the Algerian independence. The work also deals with the events on the French political scene whose changes considerably influenced following the development of the Algerian question.

See also: similar author names
6 ŠVECOVÁ, Eva
1 Švecová, Edita
6 Švecová, Eva
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