National Repository of Grey Literature 4 records found  Search took 0.01 seconds. 
In-situ compression test of artificial bone foams in controlled environment using X-Ray micro-computed tomography
Glinz, J. ; Kytýř, Daniel ; Fíla, Tomáš ; Šleichrt, Jan ; Schrempf, A. ; Fürst, D. ; Kastner, J. ; Senck, S.
X-RayMicro-computed tomography (XCT) has already become a standard method for investigations of bone and bone replacement materials in medical research. For an in-depth characterization of histomorphometric features, digital volume data acquired by XCT can be processed and visualized three dimensionally to determine parameters such as bone volume fraction, cortical thickness and porosity. In this study, we investigated specimens of artificial bone foams, developed by the research group for surgical simulators at the UAS Linz, which are used to mimic the haptic feedback of physiologic and pathologic bone for more realistic surgery training. Similar specimen of artificial bone foam in a dry state have already been characterized precisely in [1]. However, since physiological bone typically is in a wet state, the main purpose of this study was the investigation of the influence of environmental conditions on artificial bone foams of varying composition. Thus, specimens with two kinds of mineral filler material as well as different amounts of foaming agent were prepared and tested in an in-situ loading stage developed by the ITAM CAS. In this stage, specimens can be immersed in liquid and tested under temperature-controlled conditions. Consequently, a total amount of 12 specimens was subjected to compression loading; half of them immersed in water at 36.5◦C and half in dry condition. Results showed that there is no significant influence of liquid immersion to the compression outcome. However, foams with less amount of foaming agent appeared to have smaller pores resulting in higher compression strength. Different types of mineral filler material also showed no significant influence on compression strength. Furthermore, a time-lapse in-situ investigation with XCT scans in-between the load steps was performed for one specimen immersed in water to investigate behavior during load. Despite of the open porous morphology of the foam, water immersed only partially into the foam, leaving pores closer to the center unfilled. Concluding, the usage of the artificial bone foams investigated is despite their physiologically wet condition also valid in a dry state since environmental differences are nonessential for their mechanical properties.
Deformation response of polydimethylsiloxane substrates subjected to uniaxial quasi-static loading
Martino, F. ; Vinařský, V. ; Šleichrt, Jan ; Kytýř, Daniel
To investigate cellular response of cardiomyocytes to substrate mechanics, biocompatible material with stiffness in physiological range is needed. Polydimethylsiloxane (PDMS) based material Sylgard 184 is used for construction of microfluidic organ on chip devices for cell culture due to ease of device preparation, bonding, and possibility of surface functionalization. However it has stiffness orders of magnitude out of physiological range. Therefore we adapted recently published protocol [1] aiming to prepare substrates which offer stiffness in physiological range 5−100 kPa using various mixtures of Sylgard 527 and Sylagard 184. The inhouse developed loading device with the loading capacity of 3 kN with 1 μm position tracking accuracy and sub-micron position sensitivity was employed for this experimental campaign. The experiments were controlled by the proprietary LinuxCNC software running on the real-time kernel [2]. All batches of the samples were subjected to monotonic compression loading. During the displacement driven experiment with loading rate 10 μm · s−1 the samples with diameter 12.00 ± 0.05mm and height 14 − 16mm were compressed to minimally 50% deformation. Because of high differences in the samples stiffness various load cells with nominal capacity 50N, 10N, and 1N was used for the most reliable force logging. Material properties for all batches were derived from a set of tests under dry and simulated physiological conditions. The results are represented in the form of stress-strain curves calculated from the acquired force and displacement data and elastic moduli are estimated as secant up to 10% deformation.
Basic biomechanical characterization of polyurethane based artificial cancellous structures
Šleichrt, Jan ; Kytýř, Daniel ; Pithartová, Kateřina ; Senck, S. ; Fürst, D. ; Schrempf, A.
The main goal of this study is to validate elementary mechanical parameters of a newly designed open-cell foam. The purpouse for investigating artificial material is to approach the properties of the human bone in the case of its adequate replacement. Investigated material can be also used as an artificial bone to train surgical procedures and to improve the skills of the surgeons. Four sets of the foam with different chemical composition were subjected to an uniaxial quasi-static loading to describe basic mechanical behaviour of these samples. Based on these experiments, the stress-strain diagrams were created as a comparative tool including calculation of the effective Young’s modulus. The acquired knowledges will be used as input parameters of a follow-up study aimed at describing the morphology of presented structures and their response to mechanical experiments. A distortion effect of porosity on the results is not considered in this study.
Experimental assessment of creep behaviour of C/PPS chopped fibre composite
Kytýř, Daniel ; Fíla, Tomáš ; Šleichrt, Jan ; Fenclová, Nela
The report deals with experimental assessment of creep behaviour of C/PPS chopped fibre composite subjected to uniaxial loading. Digital image correlation was employed for full-field strain measurement. Creep behaviour was described using Findley model.

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2 Šleichrt, J.
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