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Multiplex Immunoassay in critically ill children
Šašek, Lumír ; Kobr, Jiří (advisor) ; Kroužecký, Aleš (referee) ; Kula, Roman (referee)
Multiplex immunoassay in critically ill children MUDr. Lumír Šašek Severe lung diseases leading to respiratory failure are the most common causes of critical conditions in childhood. From the perspective of the forecasting is in many cases difficult to identify the further development of the disease and thus allow the setting of adequate therapy. Pulmonary involvement leads to system response, and the response intensity should be at the level of the cytokines directly proportional to the degree of pulmonary disability. This work aims to follow in pediatric patients, the systemic inflammatory response dependence on the degree of lung injury using a multiplex immunoassay on the one hand and clinical, laboratory and imaging parameters on the other. It should identify, if possible, expression of early systemic cytokine markers that correlate with the degree of lung injury, which was determined by standardized scoring and monitoring parameters. This is a prospective, non-randomized observational study. The study group included 32 patients. The study included critically ill patients by PRISM III-12 and LIS with respiratory failure with the need for invasive mechanical ventilation. Patients were followed for up to 48 hours. Correlation between clinical (and laboratory) manifestations of lung disease and...

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