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The Design and Conduct of the neuroepidemiological study of aging, and MCI with the emphasis on the life style factors and prevention.
Sheardová, Kateřina ; Hort, Jakub (advisor) ; Zach, Petr (referee) ; Vališ, Martin (referee)
Identifikační záznam: SHEARDOVA, Kateřina. The Design and Conduct of the study of aging, and MCI within International Clinical Research Centre in Brno, Czech Republic, with the emphasis on the life style factors. Praha, 2020, 77 stran, 9 příloh. Disertační práce (Ph.D.). Univerzita Karlova, 2. lékařská fakulta, Neurologická klinika. Vedoucí disertační práce Hort, Jakub. Abstract The thesis describes the methodology of longitudinal aging study in the Czech Republic - Czech Brain Aging Study (CBAS) established with the aim to identify early markers of Alzheimer's disease (AD) and risk/protective factors of dementia in the context of the Czech population. The theoretical part provides a summary of present knowledge on AD biomarkers and early diagnostics and on specific life-style factors in the context of AD. The CBAS data generated over 60 publications. In the empirical part, the main results related to this thesis are discussed. First general epidemiological data and also specific research results from CBAS data are presented. The main topic is the relevance of subjective cognitive complaints, the early diagnostics of AD from the perspective of experimental neuropsychology and the life-style protective factors including non-pharmacological interventions. Key words: Alzheimer disease, longitudinal study,...
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Proteomics, Lymphocyte Population in Multiple Sclerosis and Disability
Pavelek, Zbyšek ; Vališ, Martin (advisor) ; Mareš, Jan (referee) ; Hradílek, Pavel (referee)
Introduction Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease affecting the central nervous system. Although research on the diagnosis and treatment of this serious illness has made significant advances, the MS etiology remains unknown. Although there is still much to be found in the MS pathogenetic mechanisms, understanding the mechanisms of immune-mediated damage to the central nervous system (CNS) components of MS allows not only the introduction of new drugs that positively modulate inflammatory inflammation but also the understanding of immune- mediated diseases affecting the CNS in a broader sense. Methods The Ph.D. thesis is a general introduction followed by an annotated set of author's publications on proteomics, lymphocytic population in MS and disability. Study 1: Proteomic analysis of cerebrospinal fluid for relapsing-remitting multiple sclerosis and clinically isolated syndrome was conducted to find changes in the low molecular cerebrospinal fluid (CSF) segment and to determine what native peptides and how much they are in cerebrospinal fluid among patients with clinically isolated syndrome (CIS) and relapsing-MS (RR MS) compared to a healthy population. Study 2: Lymphocytes in the treatment with interferon beta-1b targeted individual...
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