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Evaluation of photodynamic activity of tetrapyridoporphyrazine derivatives for treatment of tumorous diseases.
Půlkrábková, Martina ; Macháček, Miloslav (advisor) ; Vokřál, Ivan (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Martina Půlkrábková Supervisor: Mgr. Miloslav Macháček, Ph.D. Title of diploma thesis: Evaluation of photodynamic activity of tetrapyridoporphyrazine derivatives for treatment of tumorous diseases. Cancerous diseases are one of the most common causes of death, especially in industrialized countries. Their more effective treatment requires development of new potential anti-tumor agents and therapeutic methods. Photodynamic therapy (PDT) is a clinically approved method for the treatment of both tumorous and some other diseases. Its main advantages are non-invasiveness and potential for high selectivity to target cells, which distinguishes it from current conventional anticancer treatments (chemotherapy, radiotherapy). The effect of PDT is based on a combination of three effective components - molecular oxygen, light and photosensitiser (PS). These substances are inherently non-toxic, but they can form reactive oxygen species (ROS) if combined. Then, ROS significantly damages cellular structures in target cells, which can result in cell death. PS is a substance capable of absorbing light of suitable wavelength and transferring the received energy to surrounding molecules, to molecular oxygen in...
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Attitude control of the MAGION spacecraft
Pulkrábková, Martina ; Santolík, Ondřej (advisor) ; Truhlík, Vladimír (referee)
This thesis is divided into two parts. The first part explains development and history of the first Czechoslovak satellites Magion. Satellites Magion were developed for the Earth's ionosphere and magnetosphere research. The thesis describes the beginning of the project, Magion's technical data, its construction problems and interesting details from the background of the project. The second part of this thesis explains the Magion stabilization by its rotation, where properties of a free gyroscope are used. The text is written for students at secondary schools and also for their teachers. Because of it, everything is explained without using differential or integral calculus. The whole explanation is structured continuously, it supposes only basic knowledge, begins from the movement on the circle, continues through moments of inertia and angular momentum and ends by explanation of a free movement of the gyroscope. The whole theory is illustrated by stabilization of the satellite Magion 4 and by the experiments made during the project.
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Evaluation of photodynamic activity of tetrapyridoporphyrazine derivatives for treatment of tumorous diseases.
Půlkrábková, Martina ; Macháček, Miloslav (advisor) ; Vokřál, Ivan (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Martina Půlkrábková Supervisor: Mgr. Miloslav Macháček, Ph.D. Title of diploma thesis: Evaluation of photodynamic activity of tetrapyridoporphyrazine derivatives for treatment of tumorous diseases. Cancerous diseases are one of the most common causes of death, especially in industrialized countries. Their more effective treatment requires development of new potential anti-tumor agents and therapeutic methods. Photodynamic therapy (PDT) is a clinically approved method for the treatment of both tumorous and some other diseases. Its main advantages are non-invasiveness and potential for high selectivity to target cells, which distinguishes it from current conventional anticancer treatments (chemotherapy, radiotherapy). The effect of PDT is based on a combination of three effective components - molecular oxygen, light and photosensitiser (PS). These substances are inherently non-toxic, but they can form reactive oxygen species (ROS) if combined. Then, ROS significantly damages cellular structures in target cells, which can result in cell death. PS is a substance capable of absorbing light of suitable wavelength and transferring the received energy to surrounding molecules, to molecular oxygen in...
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Evaluation of photodynamic activity of tetrapyridoporphyrazine derivatives for treatment of tumorous diseases.
Půlkrábková, Martina ; Macháček, Miloslav (advisor) ; Vokřál, Ivan (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Martina Půlkrábková Supervisor: Mgr. Miloslav Macháček, Ph.D. Title of diploma thesis: Evaluation of photodynamic activity of tetrapyridoporphyrazine derivatives for treatment of tumorous diseases. Cancerous diseases are one of the most common causes of death, especially in industrialized countries. Their more effective treatment requires development of new potential anti-tumor agents and therapeutic methods. Photodynamic therapy (PDT) is a clinically approved method for the treatment of both tumorous and some other diseases. Its main advantages are non-invasiveness and potential for high selectivity to target cells, which distinguishes it from current conventional anticancer treatments (chemotherapy, radiotherapy). The effect of PDT is based on a combination of three effective components - molecular oxygen, light and photosensitiser (PS). These substances are inherently non-toxic, but they can form reactive oxygen species (ROS) if combined. Then, ROS significantly damages cellular structures in target cells, which can result in cell death. PS is a substance capable of absorbing light of suitable wavelength and transferring the received energy to surrounding molecules, to molecular oxygen in...
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Attitude control of the MAGION spacecraft
Pulkrábková, Martina ; Santolík, Ondřej (advisor) ; Truhlík, Vladimír (referee)
This thesis is divided into two parts. The first part explains development and history of the first Czechoslovak satellites Magion. Satellites Magion were developed for the Earth's ionosphere and magnetosphere research. The thesis describes the beginning of the project, Magion's technical data, its construction problems and interesting details from the background of the project. The second part of this thesis explains the Magion stabilization by its rotation, where properties of a free gyroscope are used. The text is written for students at secondary schools and also for their teachers. Because of it, everything is explained without using differential or integral calculus. The whole explanation is structured continuously, it supposes only basic knowledge, begins from the movement on the circle, continues through moments of inertia and angular momentum and ends by explanation of a free movement of the gyroscope. The whole theory is illustrated by stabilization of the satellite Magion 4 and by the experiments made during the project.
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