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The role of neuroinflammation in neurodegenerative CNS disease processes
Červenák, Karol ; Novotný, Jiří (advisor) ; Spišská, Veronika (referee)
Inflammatory processes in the CNS are an important element in neuroimmunity. They may be beneficial and have a neuroprotective effect but depending on the extent and duration of their activation they may also have a negative effect on the function of the CNS. Neuroinflammation is characterized by the activation of resident immune cells, microglia and astrocytes, activation of inflammatory signal pathways, recruitment of immune cells from the blood and their penetration through the blood-brain barrier. Chronic neuroinflammation may cause neurodegeneration and is key in the pathogenesis of neurodegenerative diseases. Neurodegeneration is irreversible but it can be mitigated. Therapeutic methods aimed at the modulation of neuroinflammation present a promising option for slowing down or stopping neurodegeneration for people with diseases such as Alzheimer's, Parkinson's, or Huntington's disease. The aim of this thesis is to sum up information about inflammatory processes in the brain and our current knowledge about their role in the pathogenesis of some neurodegenerative diseases. Key words: Inflammation, microglia, neurodegeneration, Alzheimer's disease, Parkinson's disease, Huntington's disease, CNS
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