Vliv stresu na astrocyty a jejich funkce během vývoje mozku v dospívání

Veverka, Jakub

Astrocytes have perhaps been historically underestimated in their number of roles regarding brain homeostasis. Recent studies are identifying the pivotal role they play in brain restructuring and how possible disruption of their function could be a predisposing factor for numerous psychiatric diseases. Proper astrocytic function might be of increased significance in adolescence, when major heterochronic brain restructuring occurs, and external stressors are of magnified effect. Regarding the role of astrocytes in synaptic formation/degradation and synaptic cleft substance clearance, the dysfunction of their homeostatic pathways during such a crucial period may predispose the effected person to specific patterns of CNS development. This could prove to be important during the development or progression of psychiatric and psychological disorders. This work will focus on the role of astrocytes during pathologically stressful conditions, the alteration of their function and the researched causes for such events namely during the unique time period of adolescence. It will also comment on the possible effect of such events during adolescence on the appearance or progression of potential psychiatric or psychological disorders later in life. Key words: Astrocytes, stress, brain, adolescence, development

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