Original title:
Chemical synthesis of prodrugs derived from 5,6-dihydro-5-azacytosine and its nucleosides using vinyl esters
Authors:
Janská, Lucie ; Blažek, Jiří ; Mařák, David ; Otmar, Miroslav ; Krečmerová, Marcela Document type: Papers Conference/Event: Chemistry of Nucleic Acid Components /15./, Český Krumlov (CZ), 2011-06-05 / 2011-06-10
Year:
2011
Language:
eng Abstract:
New strategy for synthesis of amide prodrugs without protecting groups for 5,6-dihydro-5-azacytosine and its nucleosides was developed and introduced. Vinyl esters were used as acyl donor and the reactive amino group on the heterocycle functions as nucleophile.
Keywords:
5,6-dihydro-5-azacytosine; amide prodrugs; vinyl esters Project no.: CEZ:AV0Z40550506 (CEP), 1M0508 (CEP) Funding provider: GA MŠk Host item entry: Chemistry of Nucleic Acid Components. 15th Symposium, ISBN 978-80-86241-37-1
Institution: Institute of Organic Chemistry and Biochemistry AS ČR
(web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences. Original record: http://hdl.handle.net/11104/0198532