Original title: Characterization of valinomycin binding with alkali metal ions by capillary affinity electrophoresis and density functional theory
Authors: Ehala, Sille ; Dybal, Jiří ; Makrlík, E. ; Kašička, Václav
Document type: Papers
Conference/Event: Biologically Active Peptides. Conference /11./, Praha (CZ), 2009-04-22 / 2009-04-24
Year: 2009
Language: eng
Abstract: Capillary affinity electrophoresis (CAE) and quantum mechanical density functional theory (DFT) have been applied to the study of non-covalent binding of valinomycin (Val), an antibiotic dodecadepsipeptide ionophore, with alkali metal ions, Li+, Na+, K+, Rb+ and Cs+, in methanol. The binding constants (Kb) of Val-alkali metal ion complexes were evaluated by CAE. The most probable structures of the Val-alkali metal ion complexes were proposed by DFT.
Keywords: capillary affinity electrophoresis; density funtional theory; valinomycin
Project no.: CEZ:AV0Z40550506 (CEP), CEZ:AV0Z40500505 (CEP), GA203/08/1428 (CEP), 1ET400500402 (CEP)
Funding provider: GA ČR, GA AV ČR
Host item entry: Biologically Active Peptides. 11th Conference, ISBN 978-80-86241-31-9

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0177742

Permalink: http://www.nusl.cz/ntk/nusl-40727


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers