Original title: Synthetic Biology Introduces New Base Pairs to Analyze
Authors: Špaček, Jan
Document type: Papers
Conference/Event: Moderní elektrochemické metody /36./, Jetřichovice (CZ), 20160523
Year: 2016
Language: eng
Abstract: An unnatural base pair is composed of two nucleobase analogues which specifically Pair only with each other similarly as natural DNA pairs do. Goal of the search for new base pair is expansion of genetic alphabet with new codons containing unnatural bases. Expanded genetic alphabet am, other things allows simultaneous site specific incorporation of non-standard amino acids into proteins Recently unnatural bases forming pairs vie hydrophobic interactions, which can be replicated by prokaryotic cells with efficiency and mutation rate similar to natural base pairs, have been shown. Synthetic biology provides new opportunities for application of electrochemical analysis.
Keywords: dna; escherichia-coli; expanded genetic alphabet
Project no.: GA15-08434S (CEP)
Funding provider: GA ČR
Host item entry: XXXVI. Moderní elektrochemické metody. Sborník přednášek, ISBN 978-80-905221-4-5

Institution: Institute of Biophysics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0297887

Permalink: http://www.nusl.cz/ntk/nusl-396409


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Research > Institutes ASCR > Institute of Biophysics
Conference materials > Papers
 Record created 2019-07-25, last modified 2022-09-29


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