Název: Deformation response of polydimethylsiloxane substrates subjected to uniaxial quasi-static loading
Autoři: Vinařský, V. ; Martino, F. ; Forte, G. ; Šleichrt, Jan ; Rada, Václav ; Kytýř, Daniel
Typ dokumentu: Příspěvky z konference
Konference/Akce: Youth Symposium on Experimental Solid Mechanics /17./, Telč (CZ), 20190606
Rok: 2019
Jazyk: eng
Abstrakt: To investigate cellular response of cardiomyocytes to substrate mechanics, biocompatible material with stiffness in physiological range is needed. PDMS based material is used for construction of microfluidic organ on chip devices for cell culture due to ease of device preparation, bonding, and possibility of surface functionalization. However it has stiffness orders of magnitude out of physiological range. Therefore, we adapted recently available protocol aiming to prepare substrates which offer stiffness in physiological range 5−100 kPa using various mixtures of Sylgard. An in-house developer loading device with single micron position tracking accuracy and sub-micron position sensitivity was adapted for this experimental campaign. All batches of the samples were subjected to uniaxial loading. During quasi-static experiment the samples were compressed to minimally 40% deformation. The results are represented in the form of stress-strain curves calculated from the acquired force and displacement data and elastic moduli are estimated.
Klíčová slova: hyperelasticity; in-situ loading device; polydimethylsiloxane substrates; quasi-static loading
Číslo projektu: ATCZ133
Zdrojový dokument: Acta Polytechnica CTU Proceedings, ISBN 978-80-01-06670-6
Poznámka: Související webová stránka: https://ojs.cvut.cz/ojs/index.php/APP/article/view/6032

Instituce: Ústav teoretické a aplikované mechaniky AV ČR (web)
Informace o dostupnosti dokumentu: Dokument je dostupný v příslušném ústavu Akademie věd ČR.
Původní záznam: http://hdl.handle.net/11104/0296581

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-395935


Záznam je zařazen do těchto sbírek:
Věda a výzkum > AV ČR > Ústav teoretické a aplikované mechaniky
Konferenční materiály > Příspěvky z konference