Original title: NMR Metabolomics Study of the Association between Pancreatic Cancer and Diabetes Mellrtus.
Authors: Michálková, Lenka ; Horník, Štěpán ; Sýkora, Jan ; Habartová, L. ; Setnička, V.
Document type: Papers
Conference/Event: 34th NMR Valtice, Valtice (CZ), 20190331
Year: 2019
Language: eng
Abstract: In our study, 1H NMR metabolomics was employed to plasma samples of pancreatic cancer patients, individuals with long-term diabetes mellitus type 2 (lasting more than 5 years) and healthy controls. The NMR analyses were followed by establishing a statistical model based on principal component analysis and discriminant analysis. The aim was to discover differences between these groups and to define a potential biomarker panel. The statistical evaluation of metabolomics-based profiles provided high values of sensitivity and specificity. Subsequently, plasma samples of the risk group, specifically patients with recently diagnosed diabetes mellitus with a duration of <3 years (possible T3cDM), were analysed and the possibility of PC development was predicted. The achieved results showed strong potential of 1H NMR metabolomics to establish a biomarker panel that would facilitate the early diagnosis of PC and the possibility identify diabetic individuals, who are at risk of developing PC.
Keywords: biomarker panel; nmr analyses; pancreatic cancer
Host item entry: Abstracts, ISBN 978-80-263-1462-2
Rights: This work is protected under the Copyright Act No. 121/2000 Coll.

Institution: Institute of Chemical Process Fundamentals AS ČR (web)
Original record: http://hdl.handle.net/11104/0295695

Permalink: http://www.nusl.cz/ntk/nusl-394155


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