Original title: Network Analysis Of Proteins Associated With Schizophrenia
Authors: Musilová, Jana
Document type: Papers
Publisher: Vysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologií
Abstract: The aim of this study is a network analysis of proteins ADRA1A, DRD1, DRD2 and HTR2A associated with a schizophrenia disease. By random graph analysis, all researched proteins were evaluated as significant. Using Cytoscape software, significant DPI (drug-protein interactions), PPI (protein-protein interactions) and pathways were revealed. By historeceptomics analysis, significant regions in amygdala, smooth muscle or spinal cord and prefrontal cortex were identified. The acquired knowledge can contribute to further research in the development of multitarget drugs against schizophrenia disease.
Keywords: Network Analysis; PPI; Schizophrenia
Host item entry: Proceedings of the 24th Conference STUDENT EEICT 2018, ISBN 978-80-214-5614-3

Institution: Brno University of Technology (web)
Document availability information: Fulltext is available in the Brno University of Technology Digital Library.
Original record: http://hdl.handle.net/11012/138236

Permalink: http://www.nusl.cz/ntk/nusl-393422


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