TY - GEN TI - Effect of nanodiamond particles on neuronal tissue T3 - Instruments and Methods for Biology and Medicine 2018 AU - Šimková, Veronika AB - High-Pressure High-Temperature nanodiamonds are considered to be highly biocompatible due to\ntheir low acute toxicity, which makes them suitable for biomedical applications. However, next to interaction with the cell membrane, nanoscale allows particles to penetrate the plasma membrane and even accumulate in the cell cytoplasm. Recently it brought up questions regarding sustainable nanoparticle application in vivo and potential toxicity hazards. The neuronal tissue consists of neurons and glial cells, and it is separated by a bloodbrain barrier from the peripheral blood system. Neurons are nerve cells forming a complex network of synapses that carry signals in the brain. The neurons are nourished and protected by glial cells. This project aims to find out whether nanodiamonds pass the blood-brain barrier when applied intravenously as a drug carrier and whether they directly interact with the neuronal tissue. SN - 978-80-01-06502-0 UR - http://www.nusl.cz/ntk/nusl-391551 UR - http://hdl.handle.net/11104/0292238 A2 - Benson, Veronika LA - eng KW - neuronal tissue KW - nanodiamonds KW - cell cytoplasm PY - 2018 PB - Mikrobiologický ústav, Vídeňská 1083, 142 20 Praha 4, http://www.biomed.cas.cz/mbu/cz/ ER -