Trojblokové kopolymery 2-oxazolinu s hydrofilními, lipofilními a fluorofilními bloky: od syntézy k hierarchickému samouspořádání

Kaberov, Leonid

DOCTORAL THESIS ABSTRACT 2-Oxazoline triblock copolymers with hydrophilic, lipophilic and fluorophilic blocks: from synthesis to hierarchical self-assembly MSc. Leonid Kaberov The focus of this research was on the study of di- and triblock poly(2-oxazoline) copolymers with fluorinated blocks. The synthesis and solution properties of novel copolymers combining hydrophilic, hydrophobic (lipophilic) and fluorophilic moieties into one segmented molecule were reported. The simple synthetic approach which provides an easy way to attach a CnF2n+1 terminal chain to a poly(2-methyl-2-oxazoline)-block-poly(2-n-octyl-2-oxazoline) copolymer was described. Small-angle neutron and x-ray scattering experiments unambiguously proved the existence of polymersomes, worm-like micelles and their aggregates in aqueous solution. It was shown that increasing content of fluorine in the poly(2-oxazoline) copolymers results in a morphological transition from bilayered or multi-layered vesicles to worm-like micelles. The synthesis of poly(2-perfluoroalkyl-2-oxazoline)s is complicated by their extremely low activity in cationic ring-opening polymerization reaction (CROP), both in the initiation and in the propagation due to strong electron-withdrawing effect of perfluoroalkyl substituent. A detailed systematic study on synthetic...

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