Hodnocení disolučních profilů čípků se sodnou solí diklofenakem

Stašková, Zuzana

CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Králové Departement of Pharmaceutical Technology Student: Zuzana Stašková Title: Evaluation of dissolution profile of suppositories containing diclofenac sodium salt Consultant: PharmDr. Pavel Ondrejček, Ph.D. Suppositories are a promising dosage form, which is advantageously used in cases where it is not possible to use other dosage form (e.g. in children, non-cooperating patients or patients with swallow inability). Dissolution tests serve both as qualitative tests of medicinal products and on the other hand, provide valuable information during formulation of new ones. The aim of this work was to study the dissolution process of diclofenac sodium from suppositories. The theoretical part focuses on the description of dissolution methods, the preparation of suppositories and the active substance used. The tested suppositories were prepared by three methods (manually, by Unguator technology and industry made ones), in experimental part. All suppositories contained 100mg of the active ingredient suspended in the solid fat base. Dissolution tests for lipophilic solid dosage forms by flow-through apparatus containing suppository cell according to the Czech Pharmacopoeia were performed at three media flow rates. It was found that the maximum release of...

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