Syntéza a studium vztahů mezi strukturou a antimykobakteriální aktivitou dinitrobenzylsulfanyl heteroaromátů

Karabanovich, Galina

Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Ing. Galina Karabanovich Supervisor: Prof. PharmDr. Alexandr Hrabálek, CSc. Consultant: PharmDr. Jaroslav Roh, Ph.D. Title of PhD thesis: Synthesis and structure-antimycobacterial activity relationship study of dinitrobenzylsulfanyl heteroaromates This thesis deals with the design and synthesis of novel heterocyclic compounds with high and selective antimycobacterial activity and the structure - antimycobacterial activity relationship study of these compounds. The history of knowledge about Tuberculosis, drug/regimen development, a way to successfully understand the Mycobacterium tuberculosis (M.tb.) etiology and the search for suitable therapy for treatment of drug-susceptible and drug-resistant TB are described in chapters 2 and 3. The current situation of TB epidemic and efforts towards its solution are also included. In chapter 4, the structure of mycobacterial cell wall is presented. It demonstrates the mycobacterial structural feature possessing an unusual, highly protective properties, which is essential for M.tb. growth and its survival in the host. The synthesis, logical consistency of structural changes and the results of antimycobacterial evaluation of prepared...

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