TY - THES TI - Prognostické a prediktivní faktory karcinomu prsu TT - Prognostic and Predictive Factors in Breast Cancer AU - Šefrhansová, Lucie AB - of dissertation thesis Prognostic and Predictive Factors in Breast Cancer The mRNA Expression of Selected Genes in Normal and Tumor Breast Tissue Samples and Theirs Clinical Value in Breast Cancer L.Šefrhansová Background: The aim of this work was to describe and to evaluate possibilities of prognosis and prediction in breast cancer. Within the framework of this study-work we carry out a prospective clinical study. The aim of this prospective study was to detect mRNA MMP-7, p53 and TIMP-1 expression in normal and tumor breast tissue samples and to determine the clinical and prognostic significance of our results. Prognosis and prediction: The tumor size, lymph node status, presence of distant metastasis, differentiation of the tumor, perivascular invasion, mitotic activity, expression of ER, PR and HER2 receptors are the basic prognostic factors in breast cancer. Age under/above 35 years was included among independent prognostic breast cancer factors in 2005. It is approved to use uPA/PAI to assess prognosis in node negative breast cancer patients. The hormone receptor status and HER-2 receptor status are the only two predictive markers associated with the target therapy. OncotypeDX analysis could be use to predict the disease recurrence interval of patients with estrogen positive and node negative... UR - http://hdl.handle.net/20.500.11956/44164 UR - http://www.nusl.cz/ntk/nusl-308458 A2 - Fínek, Jindřich A2 - Tesařová, Petra A2 - Nekulová, Miroslava A2 - Pešek, Miloš LA - cze KW - predikce KW - prediction KW - prognosis KW - prognóza KW - karcinom prsu KW - breast cancer PY - 2012 PB - Univerzita Karlova, Ovocný trh 5, 116 36 Praha 1, http://cuni.cz/ ER -