Original title: Th1/Th2 genový polymorfismus cytokinů u pacientů s idiopatickou plicní fibrózou
Translated title: Th1/Th2 cytokine gene polymorphisms in patients with idiopathic pulmonary fibrosis
Authors: Vašáková, Martina ; Stříž, Ilja (advisor) ; Posová, Helena (referee) ; Šedivá, Anna (referee)
Document type: Doctoral theses
Year: 2007
Language: cze
Abstract: Objectives: Idiopathic pulmonary fibrosis (IPF) is a serious disease characterized with progressive scarring of the lungs in which the genetic background is supposed. The aim of our study was to investigate Th1/Th2 cytokine gene polymorphisms to evaluate their possible influence on IPF development. Then we have correlated selected polymorphisms of IL-1, IL-4 and IL-12 groups ( the selection was based on our previous results) with clinical parameters and high resolution computed tomography (HRCT) as a markers of disease stage and progression. Methods: We investigated 30 patients with IPF and 103 healthy volunteers for the cytokines polymorphisms of the IL-1 alpha, IL-1 beta, IL-1R, IL-1RA, IL-2, IL-4, IL-6, IL-10, IL-12, TNF alpha, IFN gamma, TGF beta, IL-1 beta, IL-2, IL-4 and IL-4RA genes. The PCR-SSP method was used for measurement. Then the correlations of vital capacity(VC) and diffusing capacity for carbon monoxide(DLCO), bronchoalveolar lavage (BAL) fluid cell counts and high resolution computed tomography (HRCT) alveolar and interstitial scores with different genotypes of groups of IL-1, IL-4, and IL-12 cytokines and their receptor antagonists. The HRCT results were evaluated by an experienced viewer using the interstitial and alveolar score scales, which were based on the IPF HRCT description system...

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/9362

Permalink: http://www.nusl.cz/ntk/nusl-288909


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Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Doctoral theses