Metody spektroskopického zobrazování v klinické praxi a experimentu

Jírů, Filip

Spectroscopic imaging (SI) is the method which enables non-invasive studying of the metabolite composition of tissues in vivo from multiple regions simultaneously. The objective of this thesis was to develop a methodology for the reliable evaluation of in vivo SI data. The thesis addresses several aspects of the evaluation of SI data as described below. The processing of SI data represents a complex issue requiring dedicated evaluation programs. Although various spectra processing programs are provided by the vendors of MR scanners, software enabling complete SI data processing and analysis is not available. The CULICH program has been developed within the framework of this thesis to enable the comprehensive processing of SI data. The program offers advanced functionality for evaluation of SI data. The initial experience with the program shows that CULICH is suitable for evaluation of SI data measured in both clinical practice and the experiments. The accuracy of calculated concentrations is of high importance for each quantification method. SVS techniques can be taken as the gold standard for quantification of MR spectra. Therefore, to asses the accuracy of the metabolite concentrations measured by SI, the comparison of results obtained by SI and SVS was performed. The direct comparison of results obtained...

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