Original title: Analysis of novel members of FAHFA lipid class derived from omega 3-PUFA by LC-MS/MS and LC-MS/MS/MS
Authors: Rombaldová, Martina ; Kuda, Ondřej ; Březinová, Marie ; Slavíková, Barbora ; Pošta, Martin ; Beier, Petr ; Janovská, Petra ; Veleba, J. ; Kopecký Jr., J. ; Kudová, Eva ; Pelikánová, T. ; Kopecký, Jan
Document type: Papers
Conference/Event: International Students Conference "Modern Analytical Chemistry" /12./, Prague (CZ), 20160922
Year: 2016
Language: eng
Abstract: White adipose tissue (WAT) is a complex organ with both metabolic and endocrine functions. Dysregulation of all of these functions of WAT, together with low-grade inflammation of the tissue in obesity, contributes to the development of insulin resistance and type 2 diabetes. Omega-3 polyunsaturated fatty acids (PUFA) of marine origin play an important role in resolution of inflammation and exert beneficial metabolic effects. Using LC-MS/MS method, we elucidated the structures of novel members of fatty acid esters of hydroxy fatty acids (FAHFA), which were present in murine and human serum and WAT after omega-3 PUFA supplementation in diet. These compounds contained DHA esterified to 9- and 13-hydroxyoctadecadienoic acid (HLA) termed 9-DHAHLA and 13-DHAHLA, and were synthesized in WAT. Our results document the existence of novel lipid mediators, which are involved in the beneficial anti-inflammatory effects attributed toomega-3 PUFA, in both miceandhumans.
Keywords: branched fatty acid; lipidomics; mass spectrometry; omega 3-PUFA
Project no.: LH14040 (CEP), GB14-36804G (CEP)
Funding provider: GA MŠk, GA ČR
Host item entry: Proceedings of the 12th International Students Conference, ISBN 978-80-7444-044-1

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0269686

Permalink: http://www.nusl.cz/ntk/nusl-263483


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers
 Record created 2017-03-10, last modified 2022-09-29


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