Název:
Inhibition of gap junctional intercellular communication by polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action
Autoři:
Bláha, L. ; Vondráček, Jan ; Upham, B. L. ; Machala, M. Typ dokumentu: Příspěvky z konference Konference/Akce: SECOTOX 2002. Regional Meeting of the Central and Eastern European Section /7./, Brno (CZ), 2002-10-14 / 2002-10-16
Rok:
2002
Jazyk:
eng
Abstrakt: The aims of the present study were to determine potencies of a series of environmentally relevant PCB congeners to inhibit GJIC invitro, and to screen for intrcellular signaling pathways potentially involved in GJIC downregulation by PCBs. It was found that a number of nonplanar PCB congeners are efficient inhibitors of GJIC in vitro, and that a model compound, PCB153, does not act via activation of PKC or ERK1/2, which is contrast with the effects of protoypical inhibitors of GJIC, such as TPA or EGF.
Klíčová slova:
GJIC inhibition; PCBs; tumor promotion Číslo projektu: QC0194 (CEP), GA525/00/D101 (CEP) Poskytovatel projektu: GA MZe, GA ČR Zdrojový dokument: SECOTOX 2002. Regional Meeting of the Central and Eastern European Section /7./ Book of Abstracts
Instituce: Biofyzikální ústav AV ČR
(web)
Informace o dostupnosti dokumentu:
Dokument je dostupný v příslušném ústavu Akademie věd ČR. Původní záznam: http://hdl.handle.net/11104/0025046